Title |
Prenatal and Neonatal Thyroid Stimulating Hormone Levels and Autism Spectrum Disorders
|
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Published in |
Journal of Autism and Developmental Disorders, September 2014
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DOI | 10.1007/s10803-014-2227-2 |
Pubmed ID | |
Authors |
Vincent M. Yau, Marta Lutsky, Cathleen K. Yoshida, Bill Lasley, Martin Kharrazi, Gayle Windham, Nancy Gee, Lisa A. Croen |
Abstract |
Thyroid hormones are critical for normal brain development. This study examined autism spectrum disorders (ASD) and thyroid stimulating hormone (TSH) levels measured in mid-pregnancy maternal serum and infant blood after birth. Three groups of children born in Orange County, CA in 2000-2001were identified: ASD (n = 78), developmental delay (n = 45), and general population controls (GP) (n = 149). Samples were retrieved from prenatal and newborn screening specimen archives. Adjusted logistic regression models showed inverse associations between ASD and log transformed TSH levels in maternal serum samples (ASD vs. GP: OR [95 % CI] 0.33 [0.12-0.91], Early Onset ASD vs. GP: 0.31 [0.10-0.98]). Results for thyroid levels in newborn blood samples were similar though not significant (ASD vs. GP: 0.61 [0.18-2.04]). |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Israel | 1 | 1% |
Unknown | 94 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 17 | 18% |
Student > Master | 15 | 16% |
Researcher | 13 | 14% |
Student > Bachelor | 8 | 8% |
Student > Postgraduate | 6 | 6% |
Other | 14 | 15% |
Unknown | 22 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 21 | 22% |
Medicine and Dentistry | 18 | 19% |
Social Sciences | 7 | 7% |
Agricultural and Biological Sciences | 6 | 6% |
Nursing and Health Professions | 5 | 5% |
Other | 11 | 12% |
Unknown | 27 | 28% |