| Title |
Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update
|
|---|---|
| Published in |
Archives of Toxicology, September 2014
|
| DOI | 10.1007/s00204-014-1330-7 |
| Pubmed ID | |
| Authors |
Ana Rodriguez-Mateos, David Vauzour, Christian G. Krueger, Dhanansayan Shanmuganayagam, Jess Reed, Luca Calani, Pedro Mena, Daniele Del Rio, Alan Crozier |
| Abstract |
There is substantial interest in the role of plant secondary metabolites as protective dietary agents. In particular, the involvement of flavonoids and related compounds has become a major topic in human nutrition research. Evidence from epidemiological and human intervention studies is emerging regarding the protective effects of various (poly)phenol-rich foods against several chronic diseases, including neurodegeneration, cancer and cardiovascular diseases. In recent years, the use of HPLC-MS for the analysis of flavonoids and related compounds in foods and biological samples has significantly enhanced our understanding of (poly)phenol bioavailability. These advancements have also led to improvements in the available food composition and metabolomic databases, and consequently in the development of biomarkers of (poly)phenol intake to use in epidemiological studies. Efforts to create adequate standardised materials and well-matched controls to use in randomised controlled trials have also improved the quality of the available data. In vitro investigations using physiologically achievable concentrations of (poly)phenol metabolites and catabolites with appropriate model test systems have provided new and interesting insights on potential mechanisms of actions. This article will summarise recent findings on the bioavailability and biological activity of (poly)phenols, focusing on the epidemiological and clinical evidence of beneficial effects of flavonoids and related compounds on urinary tract infections, cognitive function and age-related cognitive decline, cancer and cardiovascular disease. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 557 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 3 | <1% |
| United Kingdom | 1 | <1% |
| Mauritius | 1 | <1% |
| Netherlands | 1 | <1% |
| Belgium | 1 | <1% |
| Sri Lanka | 1 | <1% |
| Croatia | 1 | <1% |
| Poland | 1 | <1% |
| Unknown | 547 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 86 | 15% |
| Student > Ph. D. Student | 84 | 15% |
| Researcher | 56 | 10% |
| Student > Bachelor | 49 | 9% |
| Student > Doctoral Student | 39 | 7% |
| Other | 96 | 17% |
| Unknown | 147 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 128 | 23% |
| Biochemistry, Genetics and Molecular Biology | 54 | 10% |
| Medicine and Dentistry | 52 | 9% |
| Chemistry | 33 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 24 | 4% |
| Other | 84 | 15% |
| Unknown | 182 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 September 2020.
All research outputs
#2,333,115
of 22,761,738 outputs
Outputs from Archives of Toxicology
#154
of 2,634 outputs
Outputs of similar age
#25,911
of 237,864 outputs
Outputs of similar age from Archives of Toxicology
#5
of 31 outputs
Altmetric has tracked 22,761,738 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,634 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 237,864 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.