Title |
Outcomes 1 Year after Thrombus Aspiration for Myocardial Infarction
|
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Published in |
New England Journal of Medicine, September 2014
|
DOI | 10.1056/nejmoa1405707 |
Pubmed ID | |
Authors |
Bo Lagerqvist, Ole Fröbert, Göran K Olivecrona, Thórarinn Gudnason, Michael Maeng, Patrik Alström, Jonas Andersson, Fredrik Calais, Jörg Carlsson, Olov Collste, Matthias Götberg, Peter Hårdhammar, Dan Ioanes, Anders Kallryd, Rickard Linder, Anders Lundin, Jacob Odenstedt, Elmir Omerovic, Verner Puskar, Tim Tödt, Eva Zelleroth, Ollie Östlund, Stefan K James |
Abstract |
Background Routine intracoronary thrombus aspiration before primary percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI) has not been proved to reduce short-term mortality. We evaluated clinical outcomes at 1 year after thrombus aspiration. Methods We randomly assigned 7244 patients with STEMI to undergo manual thrombus aspiration followed by PCI or to undergo PCI alone, in a registry-based, randomized clinical trial. The primary end point of all-cause mortality at 30 days has been reported previously. Death from any cause at 1 year was a prespecified secondary end point of the trial. Results No patients were lost to follow-up. Death from any cause occurred in 5.3% of the patients (191 of 3621 patients) in the thrombus-aspiration group, as compared with 5.6% (202 of 3623) in the PCI-only group (hazard ratio, 0.94; 95% confidence interval [CI], 0.78 to 1.15; P=0.57). Rehospitalization for myocardial infarction at 1 year occurred in 2.7% and 2.7% of the patients, respectively (hazard ratio, 0.97; 95% CI, 0.73 to 1.28; P=0.81), and stent thrombosis in 0.7% and 0.9%, respectively (hazard ratio, 0.84; 95% CI, 0.50 to 1.40; P=0.51). The composite of death from any cause, rehospitalization for myocardial infarction, or stent thrombosis occurred in 8.0% and 8.5% of the patients, respectively (hazard ratio, 0.94; 95% CI, 0.80 to 1.11; P=0.48). The results were consistent across all the major subgroups, including grade of thrombus burden and coronary flow before PCI. Conclusions Routine thrombus aspiration before PCI in patients with STEMI did not reduce the rate of death from any cause or the composite of death from any cause, rehospitalization for myocardial infarction, or stent thrombosis at 1 year. (Funded by the Swedish Research Council and others; TASTE ClinicalTrials.gov number, NCT01093404 .). |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 5 | 17% |
United Kingdom | 2 | 7% |
Sweden | 2 | 7% |
Venezuela, Bolivarian Republic of | 2 | 7% |
Italy | 1 | 3% |
Argentina | 1 | 3% |
Switzerland | 1 | 3% |
France | 1 | 3% |
New Zealand | 1 | 3% |
Other | 1 | 3% |
Unknown | 13 | 43% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 21 | 70% |
Practitioners (doctors, other healthcare professionals) | 7 | 23% |
Scientists | 2 | 7% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | <1% |
Japan | 2 | <1% |
Spain | 2 | <1% |
Netherlands | 1 | <1% |
Germany | 1 | <1% |
Unknown | 213 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 37 | 17% |
Researcher | 36 | 16% |
Student > Ph. D. Student | 27 | 12% |
Student > Postgraduate | 18 | 8% |
Student > Master | 13 | 6% |
Other | 38 | 17% |
Unknown | 52 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 134 | 61% |
Agricultural and Biological Sciences | 5 | 2% |
Nursing and Health Professions | 4 | 2% |
Engineering | 3 | 1% |
Psychology | 2 | <1% |
Other | 9 | 4% |
Unknown | 64 | 29% |