| Title |
Experimental study of efficacy and optimal dose of intraoperative glucose in rabbits under general anesthesia
|
|---|---|
| Published in |
Journal of Anesthesia, June 1996
|
| DOI | 10.1007/bf02483351 |
| Pubmed ID | |
| Authors |
Hideki Kamuro, Hideto Kodaira, Shun-Ichi Abe, Ryo Ogawa |
| Abstract |
This experimental study was designed to investigate the efficacy of glucose loading during surgery. Rabbits, fasted overnight, received 20 ml·kg(-1)·h(-1) fluid infusion containing glucose at various concentration (0,0.5, 1.0, 1.5, 2.0% w/v) for 3 h intraoperatively. Plasma glucose level increased after the beginning of operation, but the increase was slight in groups given 0.2 g·kg(-1)·h(-1) or lower doses of glucose. Glucose at higher doses caused marked hyperglycemia. These higher doses also promoted urinary glucose excretion, and in the group given the maximum glucose dose (0.4 g·kg(-1)·h(-1)), this parameter was significantly elevated compared with findings in the 0.2 g·kg(-1)·h(-1) group (P<0.05), whereas it showed no significant difference among groups given 0-0.2g·kg(-1)·h(-1). The liver glycogen content in animals that received no glucose was significantly lower than that of the 0.2 g·kg(-1)·h(-1) group (P <0.01). However, there was no correlation between glycogen level and glucose dose among groups receiving glucose. These results suggest that intraoperative glucose supplementation is effective in preventing glycogen depletion, and indicate that, to avoid glucose overloading, the optimal dose is 0.1-0.2 g·kg(-1)·h(-1). |
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
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| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 1 | 100% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 1 | 100% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 September 2017.
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#20,448,386
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Outputs from Journal of Anesthesia
#700
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#27,408
of 27,934 outputs
Outputs of similar age from Journal of Anesthesia
#1
of 1 outputs
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