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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Lipid Droplets: A New Player in Colorectal Cancer Stem Cells Unveiled by Spectroscopic Imaging
|
|---|---|
| Published in |
Stem Cells, December 2014
|
| DOI | 10.1002/stem.1837 |
| Pubmed ID | |
| Authors |
Luca Tirinato, Carlo Liberale, Simone Di Franco, Patrizio Candeloro, Antonina Benfante, Rosanna La Rocca, Lisette Potze, Roberto Marotta, Roberta Ruffilli, Vijayakumar P Rajamanickam, Mario Malerba, Francesco De Angelis, Andrea Falqui, Ennio Carbone, Matilde Todaro, Jan Paul Medema, Giorgio Stassi, Enzo Di Fabrizio |
| Abstract |
The cancer stem cell (CSC) model is describing tumors as a hierarchical organized system and CSCs are suggested to be responsible for cancer recurrence after therapy. The identification of specific markers of CSCs is therefore of paramount importance. Here, we show that high levels of lipid droplets (LDs) are a distinctive mark of CSCs in colorectal (CR) cancer. This increased lipid content was clearly revealed by label-free Raman spectroscopy and it directly correlates with well-accepted CR-CSC markers as CD133 and Wnt pathway activity. By xenotransplantation experiments, we have finally demonstrated that CR-CSCs overexpressing LDs retain most tumorigenic potential. A relevant conceptual advance in this work is the demonstration that a cellular organelle, the LD, is a signature of CSCs, in addition to molecular markers. A further functional characterization of LDs could lead soon to design new target therapies against CR-CSCs. Stem Cells 2015;33:35-44. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 25% |
| India | 1 | 13% |
| Italy | 1 | 13% |
| Unknown | 4 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 75% |
| Scientists | 1 | 13% |
| Science communicators (journalists, bloggers, editors) | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 209 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| France | 1 | <1% |
| United Kingdom | 1 | <1% |
| Iran, Islamic Republic of | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 204 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 51 | 24% |
| Researcher | 37 | 18% |
| Student > Master | 33 | 16% |
| Student > Bachelor | 13 | 6% |
| Student > Doctoral Student | 10 | 5% |
| Other | 24 | 11% |
| Unknown | 41 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 61 | 29% |
| Agricultural and Biological Sciences | 40 | 19% |
| Medicine and Dentistry | 16 | 8% |
| Chemistry | 9 | 4% |
| Physics and Astronomy | 6 | 3% |
| Other | 28 | 13% |
| Unknown | 49 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 September 2014.
All research outputs
#5,581,798
of 22,763,032 outputs
Outputs from Stem Cells
#1,629
of 3,897 outputs
Outputs of similar age
#74,636
of 353,263 outputs
Outputs of similar age from Stem Cells
#21
of 72 outputs
Altmetric has tracked 22,763,032 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,897 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 353,263 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 72 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.