| Title |
Abnormal levels of vascular endothelial biomarkers in schizophrenia
|
|---|---|
| Published in |
European Archives of Psychiatry and Clinical Neuroscience, September 2017
|
| DOI | 10.1007/s00406-017-0842-6 |
| Pubmed ID | |
| Authors |
Tanya T. Nguyen, Sheena I. Dev, Guanqing Chen, Sharon C. Liou, Averria Sirkin Martin, Michael R. Irwin, Judith E. Carroll, Xin Tu, Dilip V. Jeste, Lisa T. Eyler |
| Abstract |
Schizophrenia is associated with chronic low-grade inflammation, which has been linked to increased vascular risk and rates of cardiovascular disease. Levels of vascular endothelial growth factor (VEGF), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) have been related to aging and neurodegeneration, but their role in schizophrenia remains uncertain. Using a cross-sectional, case-control design, this study included 99 outpatients with schizophrenia and 99 healthy comparison subjects (HCs). Sociodemographic and clinical data were collected, and plasma levels of VEGF, ICAM-1, and VCAM-1 were assayed. A "vascular endothelial index" (VEI) was computed using logistic regression to create a composite measure that maximally differed between groups. General linear models were conducted to examine the possible role of demographic, physical, and lifestyle factors. A linear combination of ICAM-1 and VCAM-1 levels best distinguished the groups, with significantly higher levels of this composite VEI in persons with schizophrenia than HCs. Group differences in the VEI persisted after adjustment for BMI and cigarette smoking. Neither age nor gender was significantly related to the VEI. Schizophrenia patients with higher VEI had earlier age of disease onset, higher systolic and diastolic blood pressure, lower high-density lipoprotein cholesterol, higher insulin resistance, lower levels of mental well-being, and higher Framingham Coronary Heart Disease Risk scores. Schizophrenia is characterized by an elevation of vascular endothelial biomarkers, specifically cell adhesion molecules poised at the intersection between inflammatory response and vascular risk. Interventions aimed at reducing vascular risk may help reduce vascular endothelial abnormalities and prevent cardiovascular morbidity and mortality in schizophrenia. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 86 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 15% |
| Student > Bachelor | 11 | 13% |
| Student > Master | 9 | 10% |
| Student > Doctoral Student | 6 | 7% |
| Researcher | 6 | 7% |
| Other | 10 | 12% |
| Unknown | 31 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 12 | 14% |
| Medicine and Dentistry | 11 | 13% |
| Nursing and Health Professions | 7 | 8% |
| Biochemistry, Genetics and Molecular Biology | 4 | 5% |
| Neuroscience | 3 | 3% |
| Other | 12 | 14% |
| Unknown | 37 | 43% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 September 2017.
All research outputs
#19,221,261
of 23,815,455 outputs
Outputs from European Archives of Psychiatry and Clinical Neuroscience
#987
of 1,243 outputs
Outputs of similar age
#247,321
of 320,967 outputs
Outputs of similar age from European Archives of Psychiatry and Clinical Neuroscience
#5
of 10 outputs
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So far Altmetric has tracked 1,243 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
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