Title |
Early exposure to thimerosal-containing vaccines and children’s cognitive development. A 9-year prospective birth cohort study in Poland
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Published in |
European Journal of Pediatrics, September 2014
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DOI | 10.1007/s00431-014-2412-5 |
Pubmed ID | |
Authors |
Dorota Mrozek-Budzyn, Renata Majewska, Agnieszka Kiełtyka |
Abstract |
The controversial topic of the early exposure to mercury is regarding ethylmercury, which is present in the thimerosal-containing vaccines (TCVs). The objective of this study was to determine the relationship between the early exposure to TCVs and cognitive development in children during the first 9 years of life. The cohort included 318 children vaccinated in an early period (neonatal and up to 6 months) against hepatitis B and diphtheria-tetanus-pertussis (DTP) using formulation with or without thimerosal. The children's development was assessed using the Fagan test (6th month of life), the Bayley Scales of Infant Development (BSID)-II (12th-36th month), the Raven test (5th, 8th year), and the Wechsler Intelligence Scale for Children (WISC-R) (6th, 7th, 9th year). Results were determined by multivariable linear and logistic regression, adjusted to potential confounders. Children exposed and not exposed to TCVs in the neonatal period had similar outcomes of cognitive-developmental tests; only the results of BSID-II at the 36th month and WISC-R at the 9th year were significantly higher for those exposed to TCVs. Developmental test results in children exposed to TCVs up to the 6th month of life also did not depend on thimerosal dose. Conclusion: TCV administration in early infancy did not affect children's cognitive development. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 59 | 19% |
United Kingdom | 9 | 3% |
Australia | 7 | 2% |
Canada | 7 | 2% |
South Africa | 3 | <1% |
Solomon Islands | 2 | <1% |
Netherlands | 2 | <1% |
Switzerland | 1 | <1% |
Romania | 1 | <1% |
Other | 10 | 3% |
Unknown | 213 | 68% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 299 | 95% |
Scientists | 6 | 2% |
Practitioners (doctors, other healthcare professionals) | 6 | 2% |
Science communicators (journalists, bloggers, editors) | 2 | <1% |
Unknown | 1 | <1% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 2% |
Unknown | 42 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 9 | 21% |
Student > Master | 9 | 21% |
Researcher | 7 | 16% |
Student > Doctoral Student | 3 | 7% |
Other | 2 | 5% |
Other | 3 | 7% |
Unknown | 10 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 12 | 28% |
Nursing and Health Professions | 6 | 14% |
Psychology | 5 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
Environmental Science | 2 | 5% |
Other | 4 | 9% |
Unknown | 12 | 28% |