| Title |
Innate immune responses regulate morphogenesis and degeneration: roles of Toll-like receptors and Sarm1 in neurons
|
|---|---|
| Published in |
Neuroscience Bulletin, July 2014
|
| DOI | 10.1007/s12264-014-1445-5 |
| Pubmed ID | |
| Authors |
Hsin-Yu Liu, Chiung-Ya Chen, Yi-Ping Hsueh |
| Abstract |
The central nervous system is recognized as an immunoprivileged site because peripheral immune cells do not typically enter it. Microglial cells are thought to be the main immune cells in brain. However, recent reports have indicated that neurons express the key players of innate immunity, including Toll-like receptors (TLRs) and their adaptor proteins (Sarm1, Myd88, and Trif), and may produce cytokines in response to pathogen infection. In the absence of an immune challenge, neuronal TLRs can detect intrinsic danger signals and modulate neuronal morphology and function. In this article, we review the recent findings on the involvement of TLRs and Sarm1 in controlling neuronal morphogenesis and neurodegeneration. Abnormal behaviors in TLR- and Sarm1-deficient mice are also discussed. |
Mendeley readers
The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 2% |
| Chile | 1 | 2% |
| Ireland | 1 | 2% |
| United Kingdom | 1 | 2% |
| Japan | 1 | 2% |
| Unknown | 45 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 32% |
| Researcher | 9 | 18% |
| Student > Bachelor | 5 | 10% |
| Student > Postgraduate | 4 | 8% |
| Student > Doctoral Student | 3 | 6% |
| Other | 8 | 16% |
| Unknown | 5 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 13 | 26% |
| Agricultural and Biological Sciences | 10 | 20% |
| Neuroscience | 10 | 20% |
| Immunology and Microbiology | 4 | 8% |
| Medicine and Dentistry | 3 | 6% |
| Other | 3 | 6% |
| Unknown | 7 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 September 2014.
All research outputs
#17,703,216
of 22,763,032 outputs
Outputs from Neuroscience Bulletin
#436
of 762 outputs
Outputs of similar age
#154,172
of 227,398 outputs
Outputs of similar age from Neuroscience Bulletin
#3
of 7 outputs
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So far Altmetric has tracked 762 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
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We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.