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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Macrophage activation, age and sex effects of immunometabolism in obese asthma
|
|---|---|
| Published in |
European Respiratory Journal, September 2014
|
| DOI | 10.1183/09031936.00080514 |
| Pubmed ID | |
| Authors |
Hashim A. Periyalil, Lisa G. Wood, Hayley A. Scott, Megan E. Jensen, Peter G. Gibson |
| Abstract |
Obese asthma is characterised by infiltration of adipose tissue by activated macrophages and mast cells. The aim of this study was to examine the age and sex effects of immunometabolism in obese asthma. Obese and non-obese asthmatic children and adults underwent spirometry, body composition assessment by dual energy X-ray absorptiometry and measurement of serum soluble CD163 (sCD163), tryptase, C-reactive protein (CRP) and other adipocytokines. Plasma CRP (p<0.01) and leptin (p<0.01) were elevated in obese asthmatic adults, and sCD163 (p = 0.003) was elevated in obese asthmatic children. We observed significantly higher sCD163 in obese female children compared to obese female adults and male children, and higher CRP in obese female adults compared to obese male children and adults. Serum tryptase concentrations were not significantly different across age groups. sCD163 positively correlated with the proportion of android fat in obese female children (r = 0.70, p = 0.003) and obese female adults (r = 0.65, p = 0.003). In obese female children, sCD163 was inversely associated with forced expiratory volume in 1 s % predicted (r = -0.55, p = 0.02) and was positively associated with the Asthma Control Questionnaire (r = 0.57, p = 0.02). Obese children with asthma have sex-specific macrophage activation, which may contribute to worse asthma control and lung function. The heterogeneous systemic inflammatory profile across age and sex suggests the existence of sub-phenotypes in obese asthma at the molecular level. |
X Demographics
The data shown below were collected from the profiles of 21 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 8 | 38% |
| Mexico | 1 | 5% |
| Australia | 1 | 5% |
| Romania | 1 | 5% |
| India | 1 | 5% |
| Argentina | 1 | 5% |
| Unknown | 8 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 16 | 76% |
| Scientists | 3 | 14% |
| Practitioners (doctors, other healthcare professionals) | 1 | 5% |
| Science communicators (journalists, bloggers, editors) | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Korea, Republic of | 2 | 3% |
| Denmark | 1 | 1% |
| Unknown | 72 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 13% |
| Student > Master | 10 | 13% |
| Student > Bachelor | 10 | 13% |
| Other | 6 | 8% |
| Researcher | 6 | 8% |
| Other | 13 | 17% |
| Unknown | 20 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 26 | 35% |
| Biochemistry, Genetics and Molecular Biology | 8 | 11% |
| Nursing and Health Professions | 7 | 9% |
| Agricultural and Biological Sciences | 4 | 5% |
| Immunology and Microbiology | 4 | 5% |
| Other | 6 | 8% |
| Unknown | 20 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 May 2016.
All research outputs
#2,446,166
of 23,752,589 outputs
Outputs from European Respiratory Journal
#1,718
of 8,943 outputs
Outputs of similar age
#26,190
of 239,278 outputs
Outputs of similar age from European Respiratory Journal
#23
of 111 outputs
Altmetric has tracked 23,752,589 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,943 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 239,278 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 111 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.