| Title |
Keratin 19 expression correlates with poor prognosis in breast cancer
|
|---|---|
| Published in |
Molecular Biology Reports, August 2014
|
| DOI | 10.1007/s11033-014-3684-6 |
| Pubmed ID | |
| Authors |
Nuzhat N. Kabir, Lars Rönnstrand, Julhash U. Kazi |
| Abstract |
Breast cancer expression profiling has been used for determining biomarkers. Using gene expression profiles of 2,400 patients we identified keratin 19 (KRT19) as a highly deregulated gene in breast cancer. KRT19 expression is independent of patient race but correlates with disease grade, and ER, PR or HER2 expression. Expression of TPD52, GATA3 and KRT18 was increased in KRT19 expressing patients. Furthermore, KRT19 expression was associated with ER up-regulation and Luminal B gene signatures, as well as a constitutive RAF1 signaling pathway. Finally, KRT19 expression correlated with poor overall survival. Taken together, our results suggest that KRT19 expression can be used as a prognostic marker. |
Mendeley readers
The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 32 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 19% |
| Student > Master | 5 | 16% |
| Student > Bachelor | 4 | 13% |
| Lecturer | 3 | 9% |
| Student > Ph. D. Student | 3 | 9% |
| Other | 3 | 9% |
| Unknown | 8 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 7 | 22% |
| Agricultural and Biological Sciences | 6 | 19% |
| Medicine and Dentistry | 3 | 9% |
| Chemistry | 2 | 6% |
| Economics, Econometrics and Finance | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 13 | 41% |