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Mendeley readers
Attention Score in Context
| Title |
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method
|
|---|---|
| Published in |
Proceedings of the National Academy of Sciences of the United States of America, September 2014
|
| DOI | 10.1073/pnas.1404623111 |
| Pubmed ID | |
| Authors |
Cornelius A Rietveld, Tõnu Esko, Gail Davies, Tune H Pers, Patrick Turley, Beben Benyamin, Christopher F Chabris, Valur Emilsson, Andrew D Johnson, James J Lee, Christiaan de Leeuw, Riccardo E Marioni, Sarah E Medland, Michael B Miller, Olga Rostapshova, Sven J van der Lee, Anna A E Vinkhuyzen, Najaf Amin, Dalton Conley, Jaime Derringer, Cornelia M van Duijn, Rudolf Fehrmann, Lude Franke, Edward L Glaeser, Narelle K Hansell, Caroline Hayward, William G Iacono, Carla Ibrahim-Verbaas, Vincent Jaddoe, Juha Karjalainen, David Laibson, Paul Lichtenstein, David C Liewald, Patrik K E Magnusson, Nicholas G Martin, Matt McGue, George McMahon, Nancy L Pedersen, Steven Pinker, David J Porteous, Danielle Posthuma, Fernando Rivadeneira, Blair H Smith, John M Starr, Henning Tiemeier, Nicholas J Timpson, Maciej Trzaskowski, André G Uitterlinden, Frank C Verhulst, Mary E Ward, Margaret J Wright, George Davey Smith, Ian J Deary, Magnus Johannesson, Robert Plomin, Peter M Visscher, Daniel J Benjamin, David Cesarini, Philipp D Koellinger |
| Abstract |
We identify common genetic variants associated with cognitive performance using a two-stage approach, which we call the proxy-phenotype method. First, we conduct a genome-wide association study of educational attainment in a large sample (n = 106,736), which produces a set of 69 education-associated SNPs. Second, using independent samples (n = 24,189), we measure the association of these education-associated SNPs with cognitive performance. Three SNPs (rs1487441, rs7923609, and rs2721173) are significantly associated with cognitive performance after correction for multiple hypothesis testing. In an independent sample of older Americans (n = 8,652), we also show that a polygenic score derived from the education-associated SNPs is associated with memory and absence of dementia. Convergent evidence from a set of bioinformatics analyses implicates four specific genes (KNCMA1, NRXN1, POU2F3, and SCRT). All of these genes are associated with a particular neurotransmitter pathway involved in synaptic plasticity, the main cellular mechanism for learning and memory. |
X Demographics
The data shown below were collected from the profiles of 103 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 25 | 24% |
| Australia | 9 | 9% |
| United Kingdom | 5 | 5% |
| Canada | 3 | 3% |
| Sweden | 2 | 2% |
| Spain | 2 | 2% |
| Côte d'Ivoire | 1 | <1% |
| Netherlands | 1 | <1% |
| Poland | 1 | <1% |
| Other | 4 | 4% |
| Unknown | 50 | 49% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 73 | 71% |
| Scientists | 23 | 22% |
| Science communicators (journalists, bloggers, editors) | 6 | 6% |
| Practitioners (doctors, other healthcare professionals) | 1 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 410 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 10 | 2% |
| Germany | 5 | 1% |
| United Kingdom | 3 | <1% |
| Switzerland | 1 | <1% |
| Netherlands | 1 | <1% |
| Colombia | 1 | <1% |
| Sweden | 1 | <1% |
| South Africa | 1 | <1% |
| Finland | 1 | <1% |
| Other | 5 | 1% |
| Unknown | 381 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 79 | 19% |
| Student > Ph. D. Student | 77 | 19% |
| Student > Master | 40 | 10% |
| Student > Bachelor | 32 | 8% |
| Professor | 29 | 7% |
| Other | 97 | 24% |
| Unknown | 56 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 82 | 20% |
| Psychology | 68 | 17% |
| Biochemistry, Genetics and Molecular Biology | 40 | 10% |
| Neuroscience | 31 | 8% |
| Medicine and Dentistry | 26 | 6% |
| Other | 85 | 21% |
| Unknown | 78 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 329. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 April 2024.
All research outputs
#103,517
of 25,773,273 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#2,271
of 103,702 outputs
Outputs of similar age
#802
of 250,989 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#31
of 909 outputs
Altmetric has tracked 25,773,273 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 103,702 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 39.6. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 250,989 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 909 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.