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Identification of a dinucleotide signature that discriminates coding from non-coding long RNAs

Overview of attention for article published in Frontiers in Genetics, September 2014
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  • Above-average Attention Score compared to outputs of the same age (54th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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4 X users
peer_reviews
1 peer review site

Citations

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6 Dimensions

Readers on

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32 Mendeley
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1 CiteULike
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Title
Identification of a dinucleotide signature that discriminates coding from non-coding long RNAs
Published in
Frontiers in Genetics, September 2014
DOI 10.3389/fgene.2014.00316
Pubmed ID
Authors

Damien Ulveling, Marcel E. Dinger, Claire Francastel, Florent Hubé

Abstract

To date, the main criterion by which long ncRNAs (lncRNAs) are discriminated from mRNAs is based on the capacity of the transcripts to encode a protein. However, it becomes important to identify non-ORF-based sequence characteristics that can be used to parse between ncRNAs and mRNAs. In this study, we first established an extremely selective workflow to define a highly refined database of lncRNAs which was used for comparison with mRNAs. Then using this highly selective collection of lncRNAs, we found the CG dinucleotide frequencies were clearly distinct. In addition, we showed that the bias in CG dinucleotide frequency was conserved in human and mouse genomes. We propose that this sequence feature will serve as a useful classifier in transcript classification pipelines. We also suggest that our refined database of "bona fide" lncRNAs will be valuable for the discovery of other sequence characteristics distinct to lncRNAs.

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X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 3%
France 1 3%
Unknown 30 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 19%
Researcher 6 19%
Student > Bachelor 5 16%
Professor 4 13%
Student > Postgraduate 2 6%
Other 6 19%
Unknown 3 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 41%
Biochemistry, Genetics and Molecular Biology 12 38%
Engineering 2 6%
Computer Science 1 3%
Neuroscience 1 3%
Other 1 3%
Unknown 2 6%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 September 2014.
All research outputs
#12,902,902
of 22,763,032 outputs
Outputs from Frontiers in Genetics
#2,723
of 11,758 outputs
Outputs of similar age
#107,059
of 238,632 outputs
Outputs of similar age from Frontiers in Genetics
#61
of 121 outputs
Altmetric has tracked 22,763,032 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,758 research outputs from this source. They receive a mean Attention Score of 3.7. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 238,632 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
We're also able to compare this research output to 121 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.