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Mendeley readers
Attention Score in Context
| Title |
Cyclic Penta- and Hexaleucine Peptides without N‑Methylation Are Orally Absorbed
|
|---|---|
| Published in |
ACS Medicinal Chemistry Letters, August 2014
|
| DOI | 10.1021/ml5002823 |
| Pubmed ID | |
| Authors |
Timothy A. Hill, Rink-Jan Lohman, Huy N. Hoang, Daniel S. Nielsen, Conor C. G. Scully, W. Mei Kok, Ligong Liu, Andrew J. Lucke, Martin J. Stoermer, Christina I. Schroeder, Stephanie Chaousis, Barbara Colless, Paul V. Bernhardt, David J. Edmonds, David A. Griffith, Charles J. Rotter, Roger B. Ruggeri, David A. Price, Spiros Liras, David J. Craik, David P. Fairlie |
| Abstract |
Development of peptide-based drugs has been severely limited by lack of oral bioavailability with less than a handful of peptides being truly orally bioavailable, mainly cyclic peptides with N-methyl amino acids and few hydrogen bond donors. Here we report that cyclic penta- and hexa-leucine peptides, with no N-methylation and five or six amide NH protons, exhibit some degree of oral bioavailability (4-17%) approaching that of the heavily N-methylated drug cyclosporine (22%) under the same conditions. These simple cyclic peptides demonstrate that oral bioavailability is achievable for peptides that fall outside of rule-of-five guidelines without the need for N-methylation or modified amino acids. |
Mendeley readers
The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Unknown | 78 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 26 | 33% |
| Student > Ph. D. Student | 21 | 27% |
| Student > Bachelor | 4 | 5% |
| Student > Doctoral Student | 4 | 5% |
| Professor > Associate Professor | 3 | 4% |
| Other | 8 | 10% |
| Unknown | 13 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 46 | 58% |
| Biochemistry, Genetics and Molecular Biology | 7 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 8% |
| Agricultural and Biological Sciences | 4 | 5% |
| Engineering | 2 | 3% |
| Other | 1 | 1% |
| Unknown | 13 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 August 2014.
All research outputs
#17,286,645
of 25,377,790 outputs
Outputs from ACS Medicinal Chemistry Letters
#1,977
of 2,584 outputs
Outputs of similar age
#144,190
of 241,597 outputs
Outputs of similar age from ACS Medicinal Chemistry Letters
#33
of 43 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,584 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 241,597 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 43 others from the same source and published within six weeks on either side of this one. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.