Title |
Possible risk of overestimation of renal function using cystatin C-based eGFR in testicular cancer survivors treated with cisplatin-based chemotherapy
|
---|---|
Published in |
Clinical and Experimental Nephrology, September 2017
|
DOI | 10.1007/s10157-017-1474-x |
Pubmed ID | |
Authors |
Daishi Ichioka, Koji Kawai, Ken Tanaka, Ryutaro Ishitsuka, Takayuki Yoshino, Tomokazu Kimura, Shuya Kandori, Takashi Kawahara, Takahiro Kojima, Joichi Usui, Kunihiro Yamagata, Jun Miyazaki, Hiroyuki Nishiyama |
Abstract |
Chronic kidney disease (CKD) is a major long-term morbidity of testicular cancer (TC) survivors cured by cisplatin-based chemotherapy. We conducted the present study to elucidate the usefulness of cystatin-based estimated glomerular filtration rates (eGFRcys) for diagnosis of CKD compared to creatinine-based eGFR (eGFRcreat) in those patients. eGFRcys and eGFRcreat were measured in 53 TC survivors. The 24-h creatinine clearance (CrCl) was measured in 12 TC survivors and 17 CKD patients with medical disease; all of them had eGFRcreat <60 m/min/1.73 m(2). Also, urinary beta2-microglobulin and albumin concentrations in spot urine specimens were measured. The mean eGFRcreat was significantly lower than eGFRcys, at 67.9 and 95.2 ml/min/1.73 m(2), respectively (p < 0.05). The prevalence of stage 3-5 CKD differed by GFR estimation methods. It was 47.2% with eGFRcreat and only 7.5% with eGFRcys. There were 21 patients with eGFRcreat <60 ml/min/1.73 m(2) and eGFRcys ≥60 ml/min/1.73 m(2). In all 12 TC survivors, the eGFRcys values were higher than both eGFRcreat and GFR (24-h CrCl). In contrast, no difference was observed among eGFR values in the 17 patients with CKD due to medical disease. Ten of 21 patients with eGFRcreat <60 ml/min/1.73 m(2) and eGFRcys ≥60 ml/min/1.73 m(2) showed significant beta2-microglobulinuria: a higher prevalence than that in patients with both eGFRs ≥60 ml/min/1.73 m(2). Also, the incidence of microalbuminuria tended to be high in those patients. The present study suggests that eGFRcys may overestimate renal function in TC survivors cured by cisplatin-based chemotherapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 17 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 2 | 12% |
Student > Doctoral Student | 2 | 12% |
Student > Ph. D. Student | 2 | 12% |
Lecturer > Senior Lecturer | 1 | 6% |
Student > Bachelor | 1 | 6% |
Other | 3 | 18% |
Unknown | 6 | 35% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 8 | 47% |
Unspecified | 1 | 6% |
Psychology | 1 | 6% |
Nursing and Health Professions | 1 | 6% |
Unknown | 6 | 35% |