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Mendeley readers
Attention Score in Context
| Title |
The influence of MIR137 on white matter fractional anisotropy and cortical surface area in individuals with familial risk for psychosis
|
|---|---|
| Published in |
Schizophrenia Research, September 2017
|
| DOI | 10.1016/j.schres.2017.09.030 |
| Pubmed ID | |
| Authors |
Bob O. Vogel, Tristram A. Lett, Susanne Erk, Sebastian Mohnke, Carolin Wackerhagen, Eva J. Brandl, Nina Romanczuk-Seiferth, Kristina Otto, Janina I. Schweiger, Heike Tost, Markus M. Nöthen, Marcella Rietschel, Franziska Degenhardt, Stephanie H. Witt, Andreas Meyer-Lindenberg, Andreas Heinz, Henrik Walter |
| Abstract |
The rs1625579 variant near the microRNA-137 (MIR137) gene is one of the best-supported schizophrenia variants in genome-wide association studies (GWAS), and microRNA-137 functionally regulates other GWAS identified schizophrenia risk variants. Schizophrenia patients with the MIR137 rs1625579 risk genotype (homozygous for the schizophrenia risk variant) also have aberrant brain structure. It is unclear if the effect of MIR137 among schizophrenia patients is due to potential epistasis with genetic risk for schizophrenia or other factors of the disorder. Here, we investigated the effect of MIR137 genotype on white matter fractional anisotropy (FA), cortical thickness (CT), and surface area (SA) in a sample comprising healthy control subjects, and individuals with familial risk for psychosis (first-degree relatives of patients with schizophrenia or bipolar disorder; N=426). In voxel-wise analyses of FA, we observed a significant genotype-by-group interaction (PFWE<0.05). The familial risk group with risk genotype had lower FA (PFWE<0.05), but there was no genetic association in controls. In vertex-wise analyses of SA, we also observed a significant genotype-by-group interaction (PFWE<0.05). Relatives with MIR137 risk genotype had lower SA, however the risk genotype was associated with higher SA in the controls (all PFWE<0.05). These results show that MIR137 risk genotype is associated with lower FA in psychosis relatives that is similar to previous imaging-genetics findings in patients with schizophrenia. Furthermore, MIR137 genotype may also be a risk factor in a subclinical population with wide reductions in white matter FA and cortical SA. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 38 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 16% |
| Researcher | 5 | 13% |
| Student > Doctoral Student | 4 | 11% |
| Student > Postgraduate | 3 | 8% |
| Student > Master | 3 | 8% |
| Other | 6 | 16% |
| Unknown | 11 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 6 | 16% |
| Psychology | 5 | 13% |
| Medicine and Dentistry | 5 | 13% |
| Biochemistry, Genetics and Molecular Biology | 3 | 8% |
| Agricultural and Biological Sciences | 2 | 5% |
| Other | 4 | 11% |
| Unknown | 13 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 October 2017.
All research outputs
#20,663,600
of 25,382,440 outputs
Outputs from Schizophrenia Research
#4,239
of 5,687 outputs
Outputs of similar age
#254,955
of 328,531 outputs
Outputs of similar age from Schizophrenia Research
#131
of 152 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,687 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
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