| Title |
Plasma exchange and glucocorticoid dosing in the treatment of anti-neutrophil cytoplasm antibody associated vasculitis (PEXIVAS): protocol for a randomized controlled trial
|
|---|---|
| Published in |
Trials, March 2013
|
| DOI | 10.1186/1745-6215-14-73 |
| Pubmed ID | |
| Authors |
Michael Walsh, Peter A Merkel, Chen Au Peh, Wladimir Szpirt, Loïc Guillevin, Charles D Pusey, Janak deZoysa, Natalie Ives, William F Clark, Karen Quillen, Jeffrey L Winters, Keith Wheatley, David Jayne |
| Abstract |
Granulomatosis with polyangiitis (GPA, Wegener's) and microscopic polyangiitis (MPA) are small vessel vasculitides collectively referred to as anti-neutrophil cytoplasm antibody-associated vasculitis (AAV). AAV is associated with high rates of morbidity and mortality due to uncontrolled disease and treatment toxicity. Small randomized trials suggest adjunctive plasma exchange may improve disease control, while observational evidence suggests that current oral glucocorticoid doses are associated with severe infections in patients with AAV. A randomized study of both plasma exchange and glucocorticoids is required to evaluate plasma exchange and oral glucocorticoid dosing in patients with AAV. |
X Demographics
The data shown below were collected from the profiles of 88 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 10 | 11% |
| Mexico | 6 | 7% |
| India | 5 | 6% |
| Canada | 4 | 5% |
| France | 4 | 5% |
| Spain | 3 | 3% |
| Argentina | 3 | 3% |
| United Kingdom | 3 | 3% |
| Brazil | 2 | 2% |
| Other | 19 | 22% |
| Unknown | 29 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 65 | 74% |
| Practitioners (doctors, other healthcare professionals) | 13 | 15% |
| Scientists | 7 | 8% |
| Science communicators (journalists, bloggers, editors) | 3 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 179 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | <1% |
| Unknown | 178 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 30 | 17% |
| Researcher | 21 | 12% |
| Student > Postgraduate | 20 | 11% |
| Student > Ph. D. Student | 15 | 8% |
| Student > Master | 13 | 7% |
| Other | 41 | 23% |
| Unknown | 39 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 110 | 61% |
| Nursing and Health Professions | 4 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 2% |
| Agricultural and Biological Sciences | 3 | 2% |
| Unspecified | 3 | 2% |
| Other | 12 | 7% |
| Unknown | 43 | 24% |