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Increased Neuronal Differentiation of Neural Progenitor Cells Derived from Phosphovimentin-Deficient Mice

Overview of attention for article published in Molecular Neurobiology, September 2017
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Title
Increased Neuronal Differentiation of Neural Progenitor Cells Derived from Phosphovimentin-Deficient Mice
Published in
Molecular Neurobiology, September 2017
DOI 10.1007/s12035-017-0759-0
Pubmed ID
Authors

Meng Chen, Till B. Puschmann, Pavel Marasek, Masaki Inagaki, Marcela Pekna, Ulrika Wilhelmsson, Milos Pekny

Abstract

Vimentin is an intermediate filament (also known as nanofilament) protein expressed in several cell types of the central nervous system, including astrocytes and neural stem/progenitor cells. Mutation of the vimentin serine sites that are phosphorylated during mitosis (VIM (SA/SA) ) leads to cytokinetic failures in fibroblasts and lens epithelial cells, resulting in chromosomal instability and increased expression of cell senescence markers. In this study, we investigated morphology, proliferative capacity, and motility of VIM (SA/SA) astrocytes, and their effect on the differentiation of neural stem/progenitor cells. VIM (SA/SA) astrocytes expressed less vimentin and more GFAP but showed a well-developed intermediate filament network, exhibited normal cell morphology, proliferation, and motility in an in vitro wound closing assay. Interestingly, we found a two- to fourfold increased neuronal differentiation of VIM (SA/SA) neurosphere cells, both in a standard 2D and in Bioactive3D cell culture systems, and determined that this effect was neurosphere cell autonomous and not dependent on cocultured astrocytes. Using BrdU in vivo labeling to assess neural stem/progenitor cell proliferation and differentiation in the hippocampus of adult mice, one of the two major adult neurogenic regions, we found a modest increase (by 8%) in the fraction of newly born and surviving neurons. Thus, mutation of the serine sites phosphorylated in vimentin during mitosis alters intermediate filament protein expression but has no effect on astrocyte morphology or proliferation, and leads to increased neuronal differentiation of neural progenitor cells.

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The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 32 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 8 25%
Professor 4 13%
Student > Postgraduate 3 9%
Researcher 3 9%
Student > Doctoral Student 2 6%
Other 5 16%
Unknown 7 22%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 9 28%
Agricultural and Biological Sciences 6 19%
Neuroscience 3 9%
Medicine and Dentistry 2 6%
Nursing and Health Professions 1 3%
Other 3 9%
Unknown 8 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 February 2019.
All research outputs
#14,956,098
of 23,003,906 outputs
Outputs from Molecular Neurobiology
#1,953
of 3,486 outputs
Outputs of similar age
#189,504
of 320,773 outputs
Outputs of similar age from Molecular Neurobiology
#23
of 81 outputs
Altmetric has tracked 23,003,906 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,486 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,773 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 81 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.