Title |
Vascular stem/progenitor cells: functions and signaling pathways
|
---|---|
Published in |
Cellular and Molecular Life Sciences, September 2017
|
DOI | 10.1007/s00018-017-2662-2 |
Pubmed ID | |
Authors |
Weisi Lu, Xuri Li |
Abstract |
Vascular stem/progenitor cells (VSCs) are an important source of all types of vascular cells needed to build, maintain, repair, and remodel blood vessels. VSCs, therefore, play critical roles in the development, normal physiology, and pathophysiology of numerous diseases. There are four major types of VSCs, including endothelial progenitor cells (EPCs), smooth muscle progenitor cells (SMPCs), pericytes, and mesenchymal stem cells (MSCs). VSCs can be found in bone marrow, circulating blood, vessel walls, and other extravascular tissues. During the past two decades, considerable progress has been achieved in the understanding of the derivation, surface markers, and differentiation of VSCs. Yet, the mechanisms regulating their functions and maintenance under normal and pathological conditions, such as in eye diseases, remain to be further elucidated. Owing to the essential roles of blood vessels in human tissues and organs, understanding the functional properties and the underlying molecular basis of VSCs is of critical importance for both basic and translational research. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 14% |
Unknown | 6 | 86% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 57% |
Science communicators (journalists, bloggers, editors) | 2 | 29% |
Scientists | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 57 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 10 | 18% |
Researcher | 8 | 14% |
Student > Master | 7 | 12% |
Student > Bachelor | 6 | 11% |
Student > Doctoral Student | 3 | 5% |
Other | 8 | 14% |
Unknown | 15 | 26% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 12 | 21% |
Medicine and Dentistry | 7 | 12% |
Nursing and Health Professions | 1 | 2% |
Unspecified | 1 | 2% |
Other | 4 | 7% |
Unknown | 18 | 32% |