| Title |
Intravascular ultrasound assessment of the effect of laser energy on the arterial wall during the treatment of femoro-popliteal lesions: a CliRpath excimer laser system to enlarge lumen openings (CELLO) registry study
|
|---|---|
| Published in |
The International Journal of Cardiovascular Imaging, September 2017
|
| DOI | 10.1007/s10554-017-1248-2 |
| Pubmed ID | |
| Authors |
Kayode O. Kuku, Hector M. Garcia-Garcia, Edward Koifman, Alexandre H. Kajita, Sameer Desale, Viana Azizi, Gebremedhin Melaku, Anh Bui, Yael F. Meirovich, Solomon Beyene, Aaphtaab Dheendsa, Blaine Schneider, Ron Waksman, On behalf of the CELLO study investigators |
| Abstract |
The CliRpath Excimer Laser System to Enlarge Lumen Openings (CELLO) registry included patients treated with modified excimer laser catheters for the endovascular treatment of peripheral artery disease affecting the superficial femoral artery (SFA) and proximal popliteal artery. The aim of this study was to assess, via intravascular ultrasound (IVUS) the dissections in the vessel wall following treatment with the laser catheters. IVUS grayscale images from the CELLO registry were systematically reviewed for dissections in the treated vessel segments by two investigators. Images from 33 patients; 66 pullbacks (1867 IVUS frames in 2 phases), were successfully matched frame-to-frame to evaluate identical segments of the treated vessels in the two phases; post-2 mm Turbo-Elite laser pilot channel creation and post Turbo-Booster laser atherectomy. Dissections were categorized as; (1) intimal, (2) medial, (3) intramural hematoma, and (4) adventitial according to the ACC Clinical Expert Consensus Document classification of dissections. An average of 57 frames was evaluated per pullback, giving a total of 3734 frames (1867 matched for pre-ablation (post channel creation) and post-ablation phases). Treatments with the modified Excimer laser catheters resulted in a significant increase in lumen area of 5.5 ± 3.2-mm(2) (95% CI 4.3-6.8, p < 0.0001) and reduction in plaque plus media volume of -10.6 ± 36.0 mm(3) (95% CI -25.8 to 4.6, p = 0.1619) whilst giving rise to mainly intramural hematoma formations post Turbo-Booster laser treatment in 55% of frames assessed and 24% medial dissections with less than 1% adventitial disruption. The Excimer laser based Turbo-Booster treatment of peripheral artery lesions resulted in significant plaque debulking and increased lumen diameter with negligible degree of adventitial layer injury. |
Mendeley readers
The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 26 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 23% |
| Researcher | 4 | 15% |
| Other | 3 | 12% |
| Student > Master | 3 | 12% |
| Student > Bachelor | 2 | 8% |
| Other | 0 | 0% |
| Unknown | 8 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 12 | 46% |
| Engineering | 3 | 12% |
| Computer Science | 1 | 4% |
| Neuroscience | 1 | 4% |
| Mathematics | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 8 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 September 2017.
All research outputs
#22,764,772
of 25,382,440 outputs
Outputs from The International Journal of Cardiovascular Imaging
#1,460
of 2,012 outputs
Outputs of similar age
#288,836
of 328,544 outputs
Outputs of similar age from The International Journal of Cardiovascular Imaging
#33
of 41 outputs
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