| Title |
Enteroendocrine K and L cells in healthy and type 2 diabetic individuals
|
|---|---|
| Published in |
Diabetologia, September 2017
|
| DOI | 10.1007/s00125-017-4450-9 |
| Pubmed ID | |
| Authors |
Tina Jorsal, Nicolai A. Rhee, Jens Pedersen, Camilla D. Wahlgren, Brynjulf Mortensen, Sara L. Jepsen, Jacob Jelsing, Louise S. Dalbøge, Peter Vilmann, Hazem Hassan, Jakob W. Hendel, Steen S. Poulsen, Jens J. Holst, Tina Vilsbøll, Filip K. Knop |
| Abstract |
Enteroendocrine K and L cells are pivotal in regulating appetite and glucose homeostasis. Knowledge of their distribution in humans is sparse and it is unknown whether alterations occur in type 2 diabetes. We aimed to evaluate the distribution of enteroendocrine K and L cells and relevant prohormone-processing enzymes (using immunohistochemical staining), and to evaluate the mRNA expression of the corresponding genes along the entire intestinal tract in individuals with type 2 diabetes and healthy participants. In this cross-sectional study, 12 individuals with type 2 diabetes and 12 age- and BMI-matched healthy individuals underwent upper and lower double-balloon enteroscopy with mucosal biopsy retrieval from approximately every 30 cm of the small intestine and from seven specific anatomical locations in the large intestine. Significantly different densities for cells positive for chromogranin A (CgA), glucagon-like peptide-1, glucose-dependent insulinotropic polypeptide, peptide YY, prohormone convertase (PC) 1/3 and PC2 were observed along the intestinal tract. The expression of CHGA did not vary along the intestinal tract, but the mRNA expression of GCG, GIP, PYY, PCSK1 and PCSK2 differed along the intestinal tract. Lower counts of CgA-positive and PC1/3-positive cells, respectively, were observed in the small intestine of individuals with type 2 diabetes compared with healthy participants. In individuals with type 2 diabetes compared with healthy participants, the expression of GCG and PYY was greater in the colon, while the expression of GIP and PCSK1 was greater in the small intestine and colon, and the expression of PCSK2 was greater in the small intestine. Our findings provide a detailed description of the distribution of enteroendocrine K and L cells and the expression of their products in the human intestinal tract and demonstrate significant differences between individuals with type 2 diabetes and healthy participants. NCT03044860. |
X Demographics
The data shown below were collected from the profiles of 31 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 16% |
| United Kingdom | 4 | 13% |
| Denmark | 4 | 13% |
| Canada | 3 | 10% |
| Argentina | 1 | 3% |
| Germany | 1 | 3% |
| Australia | 1 | 3% |
| Ireland | 1 | 3% |
| Spain | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 9 | 29% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 18 | 58% |
| Scientists | 8 | 26% |
| Practitioners (doctors, other healthcare professionals) | 5 | 16% |
Mendeley readers
The data shown below were compiled from readership statistics for 147 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 147 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 31 | 21% |
| Researcher | 19 | 13% |
| Student > Master | 19 | 13% |
| Student > Bachelor | 17 | 12% |
| Student > Postgraduate | 4 | 3% |
| Other | 16 | 11% |
| Unknown | 41 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 50 | 34% |
| Biochemistry, Genetics and Molecular Biology | 18 | 12% |
| Agricultural and Biological Sciences | 9 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
| Unspecified | 4 | 3% |
| Other | 11 | 7% |
| Unknown | 49 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 August 2023.
All research outputs
#1,893,049
of 25,331,507 outputs
Outputs from Diabetologia
#1,016
of 5,335 outputs
Outputs of similar age
#35,958
of 327,258 outputs
Outputs of similar age from Diabetologia
#28
of 90 outputs
Altmetric has tracked 25,331,507 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,335 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.6. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 327,258 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 90 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.