| Title |
Natural course of hypogonadism diagnosed during hospitalization in aged male patients
|
|---|---|
| Published in |
Endocrine, September 2014
|
| DOI | 10.1007/s12020-014-0417-5 |
| Pubmed ID | |
| Authors |
P. Iglesias, F. Prado, A. Muñoz, M. T. Guerrero, M. C. Macías, E. Ridruejo, P. Tajada, C. García-Arévalo, J. J. Díez |
| Abstract |
Our aim was to assess short-term natural course of hypogonadism diagnosed during hospitalization for acute disease in aged male patients after discharge. A group of 43 hypogonadal males, aged 86.7 ± 5.7 year, was studied. Serum concentrations of testosterone (T) and gonadotropins (follicle-stimulating hormone, FSH, and luteinizing hormone, LH) were measured in every patient both at admission and one month after discharge. Mean serum T at entry was 115.4 ± 48.0 ng/dl. Hypogonadism was hyper-, hypo-, and normogonadotropic in 20 (46.5 %), 20 (46.5 %), and 3 (7.0 %) patients, respectively. One month after discharge serum T concentrations increased significantly (230.9 ± 135.6 ng/dl, p < 0.001). At this point, more than half of the patients (n = 27, 62.8 %) showed normal serum T concentrations. Both gonadotropins, FSH (p < 0.001), and LH (p = 0.04) also increased one month after discharge. Approximately, half of the patients (13, 48.1 %) who normalized serum T concentrations also showed normal serum gonadotropin concentrations. Patients who normalized their serum T concentrations one month after discharge showed significantly higher baseline values of T (134.7 ± 33.9 ng/dl) than those who persisted with hypogonadism (n = 16, 32.7 %; 82.8 ± 51.6 ng/dl, p < 0.001). Lastly, serum T was the only independent predictor for achieving eugonadal status (OR 1.030; CI 95 %, 1.010-1.050; p < 0.001). In conclusion, about 63 % of aged patients hospitalized for acute illness with hypogonadism discovered during hospitalization spontaneously normalize their serum T concentrations one month after discharge. Serum gonadotropin concentrations also increased after discharge. Serum T levels at admission was an independent predictor for the normalization of serum T concentrations. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 5 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 5 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 2 | 40% |
| Lecturer | 1 | 20% |
| Student > Doctoral Student | 1 | 20% |
| Unknown | 1 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 3 | 60% |
| Unknown | 2 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 September 2014.
All research outputs
#20,236,620
of 22,763,032 outputs
Outputs from Endocrine
#1,356
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Outputs of similar age
#200,248
of 238,994 outputs
Outputs of similar age from Endocrine
#24
of 32 outputs
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