Title |
Therapeutic Drug Monitoring by Dried Blood Spot: Progress to Date and Future Directions
|
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Published in |
Clinical Pharmacokinetics, September 2014
|
DOI | 10.1007/s40262-014-0177-7 |
Pubmed ID | |
Authors |
Abraham J. Wilhelm, Jeroen C. G. den Burger, Eleonora L. Swart |
Abstract |
This article discusses dried blood spot (DBS) sampling in therapeutic drug monitoring (TDM). The most important advantages of DBS sampling in TDM are the minimally invasive procedure of a finger prick (home sampling), the small volume (children), and the stability of the analyte. Many assays in DBS have been reported in the literature over the previous 5 years. These assays and their analytical techniques are reviewed here. Factors that may influence the accuracy and reproducibility of DBS methods are also discussed. Important issues are the correlation with plasma/serum concentrations and the influence of hematocrit on spot size and recovery. The different substrate materials are considered. DBS sampling can be a valid alternative to conventional venous sampling. However, patient correlation studies are indispensable to prove this. Promising developments are dried plasma spots using membrane and hematocrit correction using the potassium concentration. |
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Germany | 1 | 9% |
Canada | 1 | 9% |
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Mendeley readers
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Germany | 1 | <1% |
Unknown | 293 | 99% |
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Biochemistry, Genetics and Molecular Biology | 20 | 7% |
Other | 31 | 11% |
Unknown | 88 | 30% |