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Mechanisms of plasma non‐transferrin bound iron generation: insights from comparing transfused diamond blackfan anaemia with sickle cell and thalassaemia patients

Overview of attention for article published in British Journal of Haematology, September 2014
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  • Good Attention Score compared to outputs of the same age (70th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

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Title
Mechanisms of plasma non‐transferrin bound iron generation: insights from comparing transfused diamond blackfan anaemia with sickle cell and thalassaemia patients
Published in
British Journal of Haematology, September 2014
DOI 10.1111/bjh.13081
Pubmed ID
Authors

John B. Porter, Patrick B. Walter, Lynne D. Neumayr, Patricia Evans, Sukhvinder Bansal, Maciej Garbowski, Marcela G. Weyhmiller, Paul R. Harmatz, John C. Wood, Jeffery L. Miller, Colleen Byrnes, Guenter Weiss, Markus Seifert, Regine Grosse, Dagmar Grabowski, Angelica Schmidt, Roland Fischer, Peter Nielsen, Charlotte Niemeyer, Elliott Vichinsky

Abstract

In transfusional iron overload, extra-hepatic iron distribution differs, depending on the underlying condition. Relative mechanisms of plasma non-transferrin bound iron (NTBI) generation may account for these differences. Markers of iron metabolism (plasma NTBI, labile iron, hepcidin, transferrin, monocyte SLC40A1 [ferroportin]), erythropoiesis (growth differentiation factor 15, soluble transferrin receptor) and tissue hypoxia (erythropoietin) were compared in patients with Thalassaemia Major (TM), Sickle Cell Disease and Diamond-Blackfan Anaemia (DBA), with matched transfusion histories. The most striking differences between these conditions were relationships of NTBI to erythropoietic markers, leading us to propose three mechanisms of NTBI generation: iron overload (all), ineffective erythropoiesis (predominantly TM) and low transferrin-iron utilization (DBA).

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Poland 1 2%
Unknown 64 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 17%
Other 9 14%
Student > Master 7 11%
Professor 6 9%
Researcher 6 9%
Other 10 15%
Unknown 17 26%
Readers by discipline Count As %
Medicine and Dentistry 27 41%
Biochemistry, Genetics and Molecular Biology 7 11%
Business, Management and Accounting 3 5%
Immunology and Microbiology 3 5%
Chemistry 2 3%
Other 6 9%
Unknown 18 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 May 2023.
All research outputs
#7,464,144
of 24,549,201 outputs
Outputs from British Journal of Haematology
#2,707
of 7,908 outputs
Outputs of similar age
#70,223
of 243,937 outputs
Outputs of similar age from British Journal of Haematology
#19
of 82 outputs
Altmetric has tracked 24,549,201 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 7,908 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 243,937 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 82 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.