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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Proteins that switch folds
|
|---|---|
| Published in |
Current Opinion in Structural Biology, June 2010
|
| DOI | 10.1016/j.sbi.2010.06.002 |
| Pubmed ID | |
| Authors |
Philip N Bryan, John Orban |
| Abstract |
An increasing number of proteins demonstrate the ability to switch between very different fold topologies, expanding their functional utility through new binding interactions. Recent examples of fold switching from naturally occurring and designed systems have a number of common features: (i) The structural transitions require states with diminished stability; (ii) Switching involves flexible regions in one conformer or the other; (iii) A new binding surface is revealed in the alternate fold that can lead to both stabilization of the alternative state and expansion of biological function. Fold switching not only provides insight into how new folds evolve, but also indicates that an amino acid sequence has more information content than previously thought. A polypeptide chain can encode a stable fold while simultaneously hiding latent propensities for alternative states with novel functions. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 182 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 4% |
| United Kingdom | 4 | 2% |
| Canada | 2 | 1% |
| Korea, Republic of | 1 | <1% |
| Italy | 1 | <1% |
| South Africa | 1 | <1% |
| Germany | 1 | <1% |
| Norway | 1 | <1% |
| Switzerland | 1 | <1% |
| Other | 2 | 1% |
| Unknown | 161 | 88% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 51 | 28% |
| Researcher | 42 | 23% |
| Student > Bachelor | 15 | 8% |
| Professor > Associate Professor | 14 | 8% |
| Student > Master | 14 | 8% |
| Other | 23 | 13% |
| Unknown | 23 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 63 | 35% |
| Biochemistry, Genetics and Molecular Biology | 45 | 25% |
| Chemistry | 32 | 18% |
| Physics and Astronomy | 7 | 4% |
| Engineering | 3 | 2% |
| Other | 7 | 4% |
| Unknown | 25 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 November 2020.
All research outputs
#2,297,512
of 25,374,917 outputs
Outputs from Current Opinion in Structural Biology
#110
of 2,067 outputs
Outputs of similar age
#8,203
of 103,906 outputs
Outputs of similar age from Current Opinion in Structural Biology
#1
of 9 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,067 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 103,906 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them