| Title |
Adverse Stress, Hippocampal Networks, and Alzheimer’s Disease
|
|---|---|
| Published in |
NeuroMolecular Medicine, November 2009
|
| DOI | 10.1007/s12017-009-8107-9 |
| Pubmed ID | |
| Authors |
Sarah M. Rothman, Mark P. Mattson |
| Abstract |
Recent clinical data have implicated chronic adverse stress as a potential risk factor in the development of Alzheimer's disease (AD) and data also suggest that normal, physiological stress responses may be impaired in AD. It is possible that pathology associated with AD causes aberrant responses to chronic stress, due to potential alterations in the hypothalamic-pituitary-adrenal (HPA) axis. Recent study in rodent models of AD suggests that chronic adverse stress exacerbates the cognitive deficits and hippocampal pathology that are present in the AD brain. This review summarizes recent findings obtained in experimental AD models regarding the influence of chronic adverse stress on the underlying cellular and molecular disease processes including the potential role of glucocorticoids. Emerging findings suggest that both AD and chronic adverse stress affect hippocampal neural networks in a similar fashion. We describe alterations in hippocampal plasticity, which occur in both chronic stress and AD including dendritic remodeling, neurogenesis, and long-term potentiation. Finally, we outline potential roles for oxidative stress and neurotrophic factor signaling as the key determinants of the impact of chronic stress on the plasticity of neural networks and AD pathogenesis. |
Mendeley readers
The data shown below were compiled from readership statistics for 206 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | <1% |
| United States | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 202 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 35 | 17% |
| Student > Bachelor | 34 | 17% |
| Student > Ph. D. Student | 30 | 15% |
| Student > Master | 23 | 11% |
| Student > Doctoral Student | 11 | 5% |
| Other | 36 | 17% |
| Unknown | 37 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 35 | 17% |
| Psychology | 34 | 17% |
| Medicine and Dentistry | 28 | 14% |
| Agricultural and Biological Sciences | 27 | 13% |
| Biochemistry, Genetics and Molecular Biology | 12 | 6% |
| Other | 25 | 12% |
| Unknown | 45 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 April 2020.
All research outputs
#5,528,177
of 22,763,032 outputs
Outputs from NeuroMolecular Medicine
#146
of 447 outputs
Outputs of similar age
#35,671
of 165,604 outputs
Outputs of similar age from NeuroMolecular Medicine
#3
of 6 outputs
Altmetric has tracked 22,763,032 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 447 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 165,604 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.