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Bioenergetic Shifts during Transitions between Stem Cell States (2013 Grover Conference Series)

Overview of attention for article published in Pulmonary Circulation, September 2014
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Title
Bioenergetic Shifts during Transitions between Stem Cell States (2013 Grover Conference Series)
Published in
Pulmonary Circulation, September 2014
DOI 10.1086/677353
Pubmed ID
Authors

Lianghui Zhang, Glenn Marsboom, Danielle Glick, Yanmin Zhang, Peter T. Toth, Nicole Jones, Asrar B. Malik, Jalees Rehman

Abstract

Two defining characteristics of stem cells are their multilineage differentiation potential (multipotency or pluripotency) and their capacity for self-renewal. Growth factors are well-established regulators of stem cell differentiation and self renewal, but less is known about the influence of the metabolic state on stem cell function. Recent studies investigating cellular metabolism during the differentiation of adult stem cells, human embryonic stem cells (ESCs), and induced pluripotent stem cells have demonstrated that activation of specific metabolic pathways depends on the type of stem cells as well as the lineage cells are differentiating into and that these metabolic pathways can influence the differentiation process. However, some common patterns have emerged, suggesting that undifferentiated stem cells primarily rely on glycolysis to meet energy demands. Our own data indicate that undifferentiated ESCs not only exhibit a low mitochondrial membrane potential but also express high levels of the mitochondrial uncoupling protein 2 and of glutamine metabolism regulators when compared with differentiated cells. More importantly, interventions that target stem cell metabolism are able to either prevent or enhance differentiation. These findings suggest that the metabolic state of stem cells is not just a marker of their differentiation status but also plays an active role in regulating stem cell function. Regulatory metabolic pathways in stem cells may thus serve as important checkpoints that can be modulated to direct the regenerative capacity of stem cells.

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X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Australia 1 2%
Unknown 46 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 25%
Student > Ph. D. Student 9 19%
Student > Master 7 15%
Professor 3 6%
Student > Bachelor 3 6%
Other 9 19%
Unknown 5 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 29%
Medicine and Dentistry 10 21%
Biochemistry, Genetics and Molecular Biology 9 19%
Immunology and Microbiology 4 8%
Engineering 3 6%
Other 5 10%
Unknown 3 6%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 February 2016.
All research outputs
#16,048,009
of 25,374,647 outputs
Outputs from Pulmonary Circulation
#439
of 874 outputs
Outputs of similar age
#133,329
of 248,671 outputs
Outputs of similar age from Pulmonary Circulation
#8
of 19 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 874 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 248,671 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.