| Title |
RETRACTED ARTICLE: Association of androgen receptor exon 1 CAG repeat length with risk of hepatocellular carcinoma: a case–control study
|
|---|---|
| Published in |
Tumor Biology, September 2014
|
| DOI | 10.1007/s13277-014-2570-0 |
| Pubmed ID | |
| Authors |
Kainan Li, Chen Zhong, Jun Wang, Baocheng Wang, Jun He, Jingwang Bi |
| Abstract |
Epidemiologic and biological data suggest a role for androgens and perhaps their receptor in hepatocellular carcinoma (HCC) development. However, few studies evaluated an association between HCC risk and androgen receptor (AR) cytosine, adenine, guanine (CAG) repeat length. To examine whether the relationship between the AR CAG repeats and HCC risk was also evident in Chinese, we conducted this large population-based, case-control study of 2,000 pathologically confirmed HCC patients and 2,000 frequency-matched controls. Two different approaches for AR CAG repeat length (analyses with continuous and categorized polymorphism variables) were conducted in the statistical analyses. For AR CAG longer allele (CAG_L), we found that subjects with longer AR CAG_L repeats had a decreased risk of developing HCC (OR = 0.87 for per CAG_A increase, 95 % CI 0.82-0.96, P = 5.33 × 10(-4)). Compared to those with the shorter (<23) CAG_L repeat length, subjects in the category of longer (≥23) CAG_L repeats had a significant 20 % decreased HCC risk (OR = 0.80, 95 % CI 0.71-0.91, P = 6.16 × 10(-4)). These findings suggest that androgen signaling underlies the development of HCC. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 9 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 3 | 33% |
| Other | 3 | 33% |
| Student > Master | 2 | 22% |
| Professor | 1 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 2 | 22% |
| Medicine and Dentistry | 2 | 22% |
| Biochemistry, Genetics and Molecular Biology | 1 | 11% |
| Arts and Humanities | 1 | 11% |
| Economics, Econometrics and Finance | 1 | 11% |
| Other | 1 | 11% |
| Unknown | 1 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 September 2014.
All research outputs
#20,236,620
of 22,763,032 outputs
Outputs from Tumor Biology
#1,834
of 2,622 outputs
Outputs of similar age
#205,766
of 245,954 outputs
Outputs of similar age from Tumor Biology
#70
of 121 outputs
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