| Title |
Prion-like Mechanisms in the Pathogenesis of Tauopathies and Synucleinopathies
|
|---|---|
| Published in |
Current Neurology and Neuroscience Reports, September 2014
|
| DOI | 10.1007/s11910-014-0495-z |
| Pubmed ID | |
| Authors |
Michel Goedert, Ben Falcon, Florence Clavaguera, Markus Tolnay |
| Abstract |
Neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, are characterized by the abnormal aggregation of a small number of intracellular proteins, with tau and α-synuclein being the most commonly affected. Until recently, the events leading to aggregate formation were believed to be entirely cell-autonomous, with protein misfolding occurring independently in many cells. It is now believed that protein aggregates form in a small number of brain cells, from which they propagate intercellularly through templated recruitment, reminiscent of the mechanisms by which prions spread through the nervous system. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 194 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Japan | 1 | <1% |
| Lithuania | 1 | <1% |
| Belgium | 1 | <1% |
| Unknown | 190 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 50 | 26% |
| Student > Bachelor | 32 | 16% |
| Researcher | 27 | 14% |
| Student > Master | 19 | 10% |
| Professor | 12 | 6% |
| Other | 24 | 12% |
| Unknown | 30 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 39 | 20% |
| Biochemistry, Genetics and Molecular Biology | 36 | 19% |
| Neuroscience | 35 | 18% |
| Medicine and Dentistry | 23 | 12% |
| Chemistry | 5 | 3% |
| Other | 19 | 10% |
| Unknown | 37 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 September 2014.
All research outputs
#13,179,664
of 22,763,032 outputs
Outputs from Current Neurology and Neuroscience Reports
#558
of 914 outputs
Outputs of similar age
#114,553
of 245,954 outputs
Outputs of similar age from Current Neurology and Neuroscience Reports
#10
of 18 outputs
Altmetric has tracked 22,763,032 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 914 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.1. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 245,954 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.