| Title |
Eight-week, multimodal exercise counteracts a progress of chemotherapy-induced peripheral neuropathy and improves balance and strength in metastasized colorectal cancer patients: a randomized controlled trial
|
|---|---|
| Published in |
Supportive Care in Cancer, September 2017
|
| DOI | 10.1007/s00520-017-3875-5 |
| Pubmed ID | |
| Authors |
Philipp Zimmer, Sina Trebing, Ursula Timmers-Trebing, Alexander Schenk, Rainer Paust, Wilhelm Bloch, Roland Rudolph, Fiona Streckmann, Freerk T. Baumann |
| Abstract |
Physical activity is supposed to decrease mortality of colorectal cancer (CRC) and is suggested to reduce side-effects of the disease and its treatment. However, the knowledge about the influence of exercise interventions on patients suffering from CRC and metastasized CRC (mCRC) is still sparse. One frequently observed side effect in mCRC is chemotherapy-induced peripheral neuropathy (CIPN). This randomized controlled trial investigated the influence of a supervised exercise program on CIPN in mCRC. Thirty patients (stage IV) undergoing outpatient palliative treatment including a median of 23.5 chemotherapy cycles of various regimens were randomly assigned to an intervention or control group (IG, n = 17; CG, n = 13). The IG participated in an eight-week supervised exercise program, including endurance, resistance and balance training (2×/week for 60 min) whereas the CG received written standard recommendations to obtain physical fitness. CIPN was assessed using the FACT/GOG-NTX questionnaire. Moreover, endurance capacity (6MWT), strength (h1RM) and balance (GGT-Reha) were evaluated before (t 0) and after (t 1) the intervention as well as after 4 weeks follow-up (t2). Neuropathic symptoms remained stable in the IG over time, while CIPN significantly worsened in the CG from t 0 to t 1 and t 0 to t 2. In contrast to the CG, the IG significantly improved in strength and balance function. Changes in CIPN correlated with changes in balance. This is the first investigation showing positive effects of a multimodal exercise program on CIPN, balance and strength on mCRC patients in a palliative setting, thereby consequently increasing patients` quality of life. The results support earlier findings stating a positive influence of balance exercise on CIPN. |
X Demographics
The data shown below were collected from the profiles of 36 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 12 | 33% |
| Canada | 4 | 11% |
| Luxembourg | 2 | 6% |
| Australia | 2 | 6% |
| Nigeria | 1 | 3% |
| Sweden | 1 | 3% |
| Spain | 1 | 3% |
| France | 1 | 3% |
| Netherlands | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 11 | 31% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 23 | 64% |
| Scientists | 12 | 33% |
| Practitioners (doctors, other healthcare professionals) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 337 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 337 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 50 | 15% |
| Researcher | 30 | 9% |
| Student > Ph. D. Student | 29 | 9% |
| Student > Bachelor | 29 | 9% |
| Student > Doctoral Student | 18 | 5% |
| Other | 58 | 17% |
| Unknown | 123 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Nursing and Health Professions | 72 | 21% |
| Medicine and Dentistry | 57 | 17% |
| Sports and Recreations | 27 | 8% |
| Neuroscience | 9 | 3% |
| Biochemistry, Genetics and Molecular Biology | 6 | 2% |
| Other | 27 | 8% |
| Unknown | 139 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 24. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 March 2024.
All research outputs
#1,611,361
of 25,578,098 outputs
Outputs from Supportive Care in Cancer
#183
of 5,097 outputs
Outputs of similar age
#31,603
of 331,117 outputs
Outputs of similar age from Supportive Care in Cancer
#6
of 79 outputs
Altmetric has tracked 25,578,098 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,097 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done particularly well, scoring higher than 96% of its peers.
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We're also able to compare this research output to 79 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.