| Title |
Revisit dietary fiber on colorectal cancer: butyrate and its role on prevention and treatment
|
|---|---|
| Published in |
Cancer and Metastasis Reviews, July 2015
|
| DOI | 10.1007/s10555-015-9578-9 |
| Pubmed ID | |
| Authors |
J. C. Encarnação, A. M. Abrantes, A. S. Pires, M. F. Botelho |
| Abstract |
Colorectal cancer is still a major health problem worldwide. Based on the most recent released data by the World Health Organization GLOBOCAN in 2012, colorectal cancer is the third most prevalent type of cancer in males and the second in females. In 1999, it was published the first report showing evidence of a strong correlation between diet and cancer incidence, being its positive or negative impact intimately linked to dietary patterns. A diet rich in fiber is associated with a low risk of developing colorectal cancer. The fermentation of the dietary fiber by intestinal microflora results in production of butyrate, which plays a plurifunctional role on the colonocytes, and it has also been reported as a chemopreventive agent. However, there are limited studies focusing its anti-cancer potential. Here, we review the recent new insights that focus butyrate and its role in colorectal cancer prevention and treatment, from its synthesis, metabolism, and transport, through its involvement on several cancer-related signaling pathways, to the novel existing approaches for its clinical use. |
X Demographics
The data shown below were collected from the profiles of 16 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 44% |
| South Africa | 2 | 13% |
| United Kingdom | 1 | 6% |
| Colombia | 1 | 6% |
| Canada | 1 | 6% |
| Unknown | 4 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 50% |
| Practitioners (doctors, other healthcare professionals) | 5 | 31% |
| Scientists | 2 | 13% |
| Science communicators (journalists, bloggers, editors) | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 138 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | <1% |
| Unknown | 137 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 27 | 20% |
| Student > Master | 18 | 13% |
| Student > Ph. D. Student | 15 | 11% |
| Researcher | 11 | 8% |
| Student > Doctoral Student | 7 | 5% |
| Other | 22 | 16% |
| Unknown | 38 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 25 | 18% |
| Biochemistry, Genetics and Molecular Biology | 20 | 14% |
| Medicine and Dentistry | 18 | 13% |
| Nursing and Health Professions | 9 | 7% |
| Immunology and Microbiology | 6 | 4% |
| Other | 17 | 12% |
| Unknown | 43 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 23. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 November 2020.
All research outputs
#1,390,397
of 23,003,906 outputs
Outputs from Cancer and Metastasis Reviews
#18
of 813 outputs
Outputs of similar age
#19,140
of 263,584 outputs
Outputs of similar age from Cancer and Metastasis Reviews
#1
of 13 outputs
Altmetric has tracked 23,003,906 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 813 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,584 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.