| Title |
Healing of bisphosphonate-associated atypical femoral fractures in patients with osteoporosis: a comparison between treatment with and without teriparatide
|
|---|---|
| Published in |
Journal of Bone and Mineral Metabolism, September 2014
|
| DOI | 10.1007/s00774-014-0617-3 |
| Pubmed ID | |
| Authors |
Naohisa Miyakoshi, Toshiaki Aizawa, Satoshi Sasaki, Shigeru Ando, Shigeto Maekawa, Hiroshi Aonuma, Hiroyuki Tsuchie, Hiroshi Sasaki, Yuji Kasukawa, Yoichi Shimada |
| Abstract |
Atypical femoral fracture (AFF) often appears with bisphosphonate use. Teriparatide (TPTD) treatment may promote AFF healing, but few controlled or comparative studies have examined the effects of TPTD on healing of bisphosphonate-associated AFF. We retrospectively reviewed the medical records of 45 consecutive AFFs in 34 Japanese patients who had received oral bisphosphonates (alendronate or risedronate) for osteoporosis before AFF and had been followed for ≥12 months (range, 12-90 months). Thirty-seven complete or incomplete AFFs (82 %) were treated surgically and eight incomplete AFFs (18 %) were treated conservatively. Bisphosphonates were stopped at diagnosis. Based on TPTD use after fracture, AFFs were divided into non-TPTD (n = 24) and TPTD (n = 21) groups. Time to fracture-healing and frequency of delayed healing or non-union were compared between groups. Because fracture type (complete or incomplete) differed significantly between groups, only subanalyses for all surgically treated AFFs (complete and incomplete), surgically treated complete AFFs, and conservatively treated incomplete AFFs were performed. In subanalyses for all AFFs treated surgically, mean (± standard deviation) time to fracture healing was significantly better in the TPTD group (5.4 ± 1.5 months) than in the non-TPTD group (8.6 ± 4.7 months; P = 0.012), and the frequency of delayed healing or non-union was significantly lower in the TPTD group than in the non-TPTD group (P = 0.014). Subanalyses for surgically treated complete AFFs yielded similar results, but subanalyses for incomplete AFFs treated conservatively showed no significant differences between groups. TPTD treatment appears to significantly shorten the postoperative time to fracture healing and reduce rates of delayed healing or non-union after bisphosphonate-associated AFF. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 59 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 24% |
| Other | 6 | 10% |
| Student > Master | 6 | 10% |
| Student > Doctoral Student | 5 | 8% |
| Student > Bachelor | 4 | 7% |
| Other | 17 | 29% |
| Unknown | 7 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 39 | 66% |
| Nursing and Health Professions | 2 | 3% |
| Chemistry | 2 | 3% |
| Computer Science | 1 | 2% |
| Social Sciences | 1 | 2% |
| Other | 3 | 5% |
| Unknown | 11 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 September 2014.
All research outputs
#19,851,592
of 24,396,012 outputs
Outputs from Journal of Bone and Mineral Metabolism
#504
of 799 outputs
Outputs of similar age
#183,701
of 254,304 outputs
Outputs of similar age from Journal of Bone and Mineral Metabolism
#12
of 21 outputs
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