| Title |
ROS-mediated cytotoxic activity of ZnO and CeO2 nanoparticles synthesized using the Rubia cordifolia L. leaf extract on MG-63 human osteosarcoma cell lines
|
|---|---|
| Published in |
Environmental Science and Pollution Research, September 2017
|
| DOI | 10.1007/s11356-017-0003-5 |
| Pubmed ID | |
| Authors |
Natarajan Sisubalan, Vijayan Sri Ramkumar, Arivalagan Pugazhendhi, Chandrasekaran Karthikeyan, Karuppusamy Indira, Kasi Gopinath, Abdulrahman Syedahamed Haja Hameed, Mohamed Hussain Ghouse Basha |
| Abstract |
In the present scenario, the synthesis and characterization of zinc oxide (ZnO) and cerium oxide (CeO2) nanoparticles (NPs) through biological routes using green reducing agents are quite interesting to explore various biomedical and pharmaceutical applications, particularly for the treatment of cancer. This study was focused on the phytosynthesis of ZnO and CeO2 NPs using the leaf extract of Rubia cordifolia L. The active principles present in the plant extract were liable for rapid reduction of Zn and Ce ions to metallic nanocrystals. ZnO and CeO2 NPs were characterized by UV-visible spectroscopy, X-ray diffraction analysis (XRD), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), energy dispersive X-ray spectroscopy (EDAX), and photoluminescence (PL) techniques. ZnO and CeO2 NPs were partially agglomerated with a net-like structure. Biomedical activities of ZnO and CeO2 NPs were tested against MG-63 human osteosarcoma cells using MTT and reactive oxygen species (ROS) quantification assays. In treated cells, loss of cell membrane integrity, oxidative stress, and apoptosis was observed and it is well correlated with cellular damage immediately after induction. Overall, this study shed light on the anti-cancer potential of ZnO and CeO2 NPs on MG-63 human osteosarcoma cells through differential ROS production pathways, describing the potential role of greener synthesis. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 92 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 92 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 18% |
| Researcher | 10 | 11% |
| Student > Master | 8 | 9% |
| Student > Bachelor | 6 | 7% |
| Other | 5 | 5% |
| Other | 14 | 15% |
| Unknown | 32 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 13 | 14% |
| Materials Science | 10 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 7% |
| Biochemistry, Genetics and Molecular Biology | 5 | 5% |
| Agricultural and Biological Sciences | 4 | 4% |
| Other | 17 | 18% |
| Unknown | 37 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 October 2017.
All research outputs
#19,440,618
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Outputs from Environmental Science and Pollution Research
#5,443
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Outputs of similar age
#250,738
of 323,985 outputs
Outputs of similar age from Environmental Science and Pollution Research
#145
of 259 outputs
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