Title |
A critical role for Egr-1 during vascular remodelling in pulmonary arterial hypertension
|
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Published in |
Cardiovascular Research, July 2014
|
DOI | 10.1093/cvr/cvu169 |
Pubmed ID | |
Authors |
Michael G. Dickinson, Piotr S. Kowalski, Beatrijs Bartelds, Marinus A.J. Borgdorff, Diederik van der Feen, Hannie Sietsma, Grietje Molema, Jan A.A.M. Kamps, Rolf M.F. Berger |
Abstract |
Pulmonary arterial hypertension (PAH) is characterized by the development of unique neointimal lesions in the small pulmonary arteries, leading to increased right ventricular (RV) afterload and failure. Novel therapeutic strategies are needed that target these neointimal lesions. Recently, the transcription factor Egr-1 (early growth response protein 1) was demonstrated to be up-regulated early in experimental neointimal PAH. Its effect on disease development, however, is unknown. We aimed to uncover a novel role for Egr-1 as a molecular inductor for disease development in PAH. |
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Unknown | 2 | 67% |
Demographic breakdown
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Mendeley readers
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