| Title |
Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal
|
|---|---|
| Published in |
Science, September 2014
|
| DOI | 10.1126/science.1256337 |
| Pubmed ID | |
| Authors |
Iman Fares, Jalila Chagraoui, Yves Gareau, Stéphane Gingras, Réjean Ruel, Nadine Mayotte, Elizabeth Csaszar, David J H F Knapp, Paul Miller, Mor Ngom, Suzan Imren, Denis-Claude Roy, Kori L Watts, Hans-Peter Kiem, Robert Herrington, Norman N Iscove, R Keith Humphries, Connie J Eaves, Sandra Cohen, Anne Marinier, Peter W Zandstra, Guy Sauvageau |
| Abstract |
The small number of hematopoietic stem and progenitor cells in cord blood units limits their widespread use in human transplant protocols. We identified a family of chemically related small molecules that stimulates the expansion ex vivo of human cord blood cells capable of reconstituting human hematopoiesis for at least 6 months in immunocompromised mice. The potent activity of these newly identified compounds, UM171 being the prototype, is independent of suppression of the aryl hydrocarbon receptor, which targets cells with more-limited regenerative potential. The properties of UM171 make it a potential candidate for hematopoietic stem cell transplantation and gene therapy. |
X Demographics
The data shown below were collected from the profiles of 24 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 13% |
| Canada | 2 | 8% |
| Brazil | 1 | 4% |
| Netherlands | 1 | 4% |
| Argentina | 1 | 4% |
| Sweden | 1 | 4% |
| Ireland | 1 | 4% |
| Pakistan | 1 | 4% |
| Italy | 1 | 4% |
| Other | 3 | 13% |
| Unknown | 9 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 14 | 58% |
| Scientists | 4 | 17% |
| Science communicators (journalists, bloggers, editors) | 3 | 13% |
| Practitioners (doctors, other healthcare professionals) | 3 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 542 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | <1% |
| Germany | 2 | <1% |
| United Kingdom | 2 | <1% |
| Japan | 2 | <1% |
| Austria | 2 | <1% |
| Brazil | 1 | <1% |
| Finland | 1 | <1% |
| Switzerland | 1 | <1% |
| Canada | 1 | <1% |
| Other | 3 | <1% |
| Unknown | 522 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 125 | 23% |
| Researcher | 120 | 22% |
| Student > Master | 48 | 9% |
| Student > Bachelor | 35 | 6% |
| Other | 27 | 5% |
| Other | 81 | 15% |
| Unknown | 106 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 152 | 28% |
| Agricultural and Biological Sciences | 134 | 25% |
| Medicine and Dentistry | 51 | 9% |
| Immunology and Microbiology | 33 | 6% |
| Engineering | 20 | 4% |
| Other | 37 | 7% |
| Unknown | 115 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 177. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 March 2024.
All research outputs
#231,141
of 25,837,817 outputs
Outputs from Science
#6,510
of 83,358 outputs
Outputs of similar age
#2,048
of 263,014 outputs
Outputs of similar age from Science
#79
of 907 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 83,358 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 65.9. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,014 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 907 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.