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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The Genomic Landscape of Pediatric Ewing Sarcoma
|
|---|---|
| Published in |
Cancer Discovery, November 2014
|
| DOI | 10.1158/2159-8290.cd-13-1037 |
| Pubmed ID | |
| Authors |
Brian D. Crompton, Chip Stewart, Amaro Taylor-Weiner, Gabriela Alexe, Kyle C. Kurek, Monica L. Calicchio, Adam Kiezun, Scott L. Carter, Sachet A. Shukla, Swapnil S. Mehta, Aaron R. Thorner, Carmen de Torres, Cinzia Lavarino, Mariona Suñol, Aaron McKenna, Andrey Sivachenko, Kristian Cibulskis, Michael S. Lawrence, Petar Stojanov, Mara Rosenberg, Lauren Ambrogio, Daniel Auclair, Sara Seepo, Brendan Blumenstiel, Matthew DeFelice, Ivan Imaz-Rosshandler, Angela Schwarz-Cruz y Celis, Miguel N. Rivera, Carlos Rodriguez-Galindo, Mark D. Fleming, Todd R. Golub, Gad Getz, Jaume Mora, Kimberly Stegmaier |
| Abstract |
Pediatric Ewing sarcoma is characterized by the expression of chimeric fusions of EWS and ETS family transcription factors, representing a paradigm for studying cancers driven by transcription factor rearrangements. In this study, we describe the somatic landscape of pediatric Ewing sarcoma. These tumors are among the most genetically normal cancers characterized to date with only EWS/ETS rearrangements identified in the majority of tumors. STAG2 loss, however, is present in over 15% of Ewing sarcoma tumors; occurs by point mutation, rearrangement, and likely non-genetic mechanisms; and is associated with disease dissemination. Perhaps the most striking finding is the paucity of mutations in immediately targetable signal transduction pathways, highlighting the need for new therapeutic approaches to target EWS/ETS fusions in this disease. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 50% |
| France | 1 | 13% |
| Belgium | 1 | 13% |
| Unknown | 2 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 5 | 63% |
| Members of the public | 3 | 38% |
Mendeley readers
The data shown below were compiled from readership statistics for 344 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| Portugal | 1 | <1% |
| Switzerland | 1 | <1% |
| Slovenia | 1 | <1% |
| Unknown | 340 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 74 | 22% |
| Researcher | 61 | 18% |
| Student > Bachelor | 35 | 10% |
| Student > Master | 34 | 10% |
| Student > Doctoral Student | 17 | 5% |
| Other | 53 | 15% |
| Unknown | 70 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 110 | 32% |
| Agricultural and Biological Sciences | 68 | 20% |
| Medicine and Dentistry | 58 | 17% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 2% |
| Computer Science | 5 | 1% |
| Other | 20 | 6% |
| Unknown | 77 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 September 2022.
All research outputs
#1,989,751
of 25,262,379 outputs
Outputs from Cancer Discovery
#903
of 4,036 outputs
Outputs of similar age
#22,424
of 268,723 outputs
Outputs of similar age from Cancer Discovery
#9
of 68 outputs
Altmetric has tracked 25,262,379 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,036 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.5. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,723 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 68 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.