| Title |
Curcumin prevents liver fat accumulation and serum fetuin-A increase in rats fed a high-fat diet
|
|---|---|
| Published in |
Journal of Physiology and Biochemistry, February 2013
|
| DOI | 10.1007/s13105-013-0244-9 |
| Pubmed ID | |
| Authors |
Yildiz Öner-İyidoğan, Hikmet Koçak, Muhammed Seyidhanoğlu, Figen Gürdöl, Ahmet Gülçubuk, Funda Yildirim, Aydin Çevik, Müjdat Uysal |
| Abstract |
Fetuin-A is synthesized in the liver and is secreted into the bloodstream. Clinical studies suggest involvement of fetuin-A in metabolic disorders such as visceral obesity, insulin resistance, diabetes, and fatty liver. Curcumin is extracted from the rhizome Curcuma longa and has been shown to possess potent antioxidant, anticarcinogenic, anti-inflammatory, and hypoglycemic properties. In this study, we investigated the effect of curcumin treatment on serum fetuin-A levels as well as hepatic lipids and prooxidant-antioxidant status in rats fed a high-fat diet (HFD). Male Sprague-Dawley rats were divided into six groups. Group 1 was fed control diet (10 % of total calories from fat). Groups 2 and 3 were given curcumin (100 and 400 mg/kg bw/day, respectively ) by gavage for 8 weeks and were fed control diet. Group 4 was fed with HFD (60 % of total calories from fat). Groups 5 and 6 received HFD together with the two doses of curcumin, respectively. Curcumin treatment appeared to be effective in reducing liver triglycerides and serum fetuin-A levels. These findings suggest that the reduction of fetuin-A may contribute to the beneficial effects of curcumin in the pathogenesis of obesity. |
Mendeley readers
The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 62 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 12 | 19% |
| Student > Doctoral Student | 9 | 15% |
| Student > Ph. D. Student | 8 | 13% |
| Student > Bachelor | 6 | 10% |
| Student > Master | 6 | 10% |
| Other | 8 | 13% |
| Unknown | 13 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 14 | 23% |
| Medicine and Dentistry | 9 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 10% |
| Biochemistry, Genetics and Molecular Biology | 6 | 10% |
| Nursing and Health Professions | 3 | 5% |
| Other | 9 | 15% |
| Unknown | 15 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 September 2014.
All research outputs
#7,202,382
of 22,764,165 outputs
Outputs from Journal of Physiology and Biochemistry
#121
of 528 outputs
Outputs of similar age
#61,504
of 193,027 outputs
Outputs of similar age from Journal of Physiology and Biochemistry
#2
of 6 outputs
Altmetric has tracked 22,764,165 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 528 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 193,027 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.