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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Deletion of TLX and social isolation impairs exercise‐induced neurogenesis in the adolescent hippocampus
|
|---|---|
| Published in |
Hippocampus, October 2017
|
| DOI | 10.1002/hipo.22805 |
| Pubmed ID | |
| Authors |
Danka A. Kozareva, Olivia F. O'Leary, John F. Cryan, Yvonne M. Nolan |
| Abstract |
Adolescence is a sensitive period of neurodevelopment during which life experiences and the surrounding environment can have profound effects on the brain. Neurogenesis is a neurodevelopmental process of generating functional neurons from neural stem cells. Hippocampal neurogenesis occurs throughout the lifespan and has been shown to play a role in learning, memory and in mood regulation. In adulthood it is influenced by extrinsic environmental factors such as exercise and stress. Intrinsic factors that regulate hippocampal neurogenesis include the orphan nuclear receptor TLX (Nr2e1) which is primarily expressed in the neurogenic niches of the brain. While mechanisms regulating adult hippocampal neurogenesis have been widely studied, less is known on how hippocampal neurogenesis is affected during adolescence. Thus, the aim of this study was to investigate the influence of both TLX and isolation stress on exercise-induced increases in neurogenesis in running and sedentary conditions during adolescence. Single- (i.e. isolation stress) wild type and Nr2e1(-/-) or pair-housed wild type mice were housed in sedentary conditions or allowed free access to running wheels for 3 weeks during the adolescent period. A reduction of neuronal survival was evident in mice lacking TLX, and exercise did not increase hippocampal neurogenesis in these Nr2e1(-/-) mice. This suggests that TLX is necessary for the pro-neurogenic effects of exercise during adolescence. Interestingly, although social isolation during adolescence did not affect hippocampal neurogenesis, it prevented an exercise-induced increase in neurogenesis in the ventral hippocampus. Together these data demonstrate the importance of intrinsic and extrinsic factors in promoting an exercise-induced increase in neurogenesis at this key point in life. This article is protected by copyright. All rights reserved. |
X Demographics
The data shown below were collected from the profiles of 17 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Ireland | 9 | 53% |
| United States | 1 | 6% |
| Portugal | 1 | 6% |
| Netherlands | 1 | 6% |
| Unknown | 5 | 29% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 11 | 65% |
| Scientists | 3 | 18% |
| Practitioners (doctors, other healthcare professionals) | 2 | 12% |
| Science communicators (journalists, bloggers, editors) | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 84 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 20% |
| Student > Bachelor | 14 | 17% |
| Student > Master | 10 | 12% |
| Researcher | 8 | 10% |
| Student > Doctoral Student | 4 | 5% |
| Other | 10 | 12% |
| Unknown | 21 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 20 | 24% |
| Agricultural and Biological Sciences | 9 | 11% |
| Psychology | 7 | 8% |
| Biochemistry, Genetics and Molecular Biology | 6 | 7% |
| Sports and Recreations | 4 | 5% |
| Other | 13 | 15% |
| Unknown | 25 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 February 2023.
All research outputs
#3,217,719
of 24,525,936 outputs
Outputs from Hippocampus
#265
of 1,456 outputs
Outputs of similar age
#59,159
of 330,528 outputs
Outputs of similar age from Hippocampus
#5
of 20 outputs
Altmetric has tracked 24,525,936 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,456 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.4. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 330,528 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.