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X Demographics
Mendeley readers
Attention Score in Context
| Title |
CGRPα within the Trpv1-Cre population contributes to visceral nociception
|
|---|---|
| Published in |
American Journal of Physiology: Gastrointestinal & Liver Physiology, September 2017
|
| DOI | 10.1152/ajpgi.00188.2017 |
| Pubmed ID | |
| Authors |
Nick J Spencer, Elín I Magnúsdóttir, Jon E T Jakobsson, Garreth Kestell, Bao Nan Chen, David Morris, Simon J Brookes, Malin C Lagerström |
| Abstract |
The role of Calcitonin Gene Related Peptide (CGRP) in visceral and somatic nociception is incompletely understood. CGRPα is highly expressed in sensory neurons of dorsal root ganglia (DRG) and particularly in neurons that also express the transient receptor potential cation channel subfamily V member 1 (Trpv1). Therefore, we investigated changes in visceral and somatic nociception following deletion of CGRPα from the Trpv1-Cre population using the Cre/lox system. In control mice, acetic acid injection (0.6%,i.p.) caused significant immobility (time stationary) - an established indicator of visceral pain. In CGRPα-mCherry(lx/lx);Trpv1-Cre mice the duration of immobility was significantly less than controls and the distance CGRPα-mCherry(lx/lx);Trpv1-Cre mice travelled over 20 minutes following acetic acid was significantly greater than controls. However, following acetic acid injection, there was no difference between genotypes in the writhing reflex, number of abdominal licks, or forepaw wipes of the cheek. CGRPα-mCherry(lx/lx);Trpv1-Cre mice developed more pronounced inflammation-induced heat hypersensitivity above baseline values, compared to controls. However, analyses of noxious acute heat or cold transmission revealed no difference between genotypes. Also, odour avoidance test, odour preference test and buried food test for olfaction revealed no differences between genotypes. Our findings suggest that CGRPα-mediated transmission within the Trpv1-Cre population plays a significant role in visceral nociceptive pathways underlying voluntary movement. Monitoring changes in movement over time is a sensitive parameter to identify differences in visceral nociception, compared to writhing reflexes, abdominal licks, or forepaw wipes of the cheek that were unaffected by deletion of CGRPα- from Trpv1-Cre population and likely utilize different mechanisms. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 20% |
| Sweden | 1 | 20% |
| Unknown | 3 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 28 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 5 | 18% |
| Student > Ph. D. Student | 5 | 18% |
| Researcher | 5 | 18% |
| Student > Doctoral Student | 1 | 4% |
| Student > Master | 1 | 4% |
| Other | 3 | 11% |
| Unknown | 8 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 8 | 29% |
| Medicine and Dentistry | 5 | 18% |
| Agricultural and Biological Sciences | 4 | 14% |
| Biochemistry, Genetics and Molecular Biology | 2 | 7% |
| Nursing and Health Professions | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 7 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 February 2018.
All research outputs
#7,359,319
of 25,382,440 outputs
Outputs from American Journal of Physiology: Gastrointestinal & Liver Physiology
#577
of 2,218 outputs
Outputs of similar age
#109,479
of 328,838 outputs
Outputs of similar age from American Journal of Physiology: Gastrointestinal & Liver Physiology
#9
of 35 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 2,218 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 328,838 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.