↓ Skip to main content

Hyperglucagonemia correlates with plasma levels of non-branched-chain amino acids in patients with liver disease independent of type 2 diabetes

Overview of attention for article published in American Journal of Physiology: Gastrointestinal & Liver Physiology, September 2017
Altmetric Badge

About this Attention Score

  • Good Attention Score compared to outputs of the same age (68th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

twitter
8 X users
facebook
2 Facebook pages

Citations

dimensions_citation
66 Dimensions

Readers on

mendeley
62 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Hyperglucagonemia correlates with plasma levels of non-branched-chain amino acids in patients with liver disease independent of type 2 diabetes
Published in
American Journal of Physiology: Gastrointestinal & Liver Physiology, September 2017
DOI 10.1152/ajpgi.00216.2017
Pubmed ID
Authors

Nicolai J Wewer Albrechtsen, Anders E Junker, Mette Christensen, Sofie Hædersdal, Flemming Wibrand, Allan M Lund, Katrine D Galsgaard, Jens J Holst, Filip K Knop, Tina Vilsbøll

Abstract

Patients with type 2 diabetes (T2D) and patients with non-alcoholic fatty liver disease (NAFLD) frequently exhibit elevated plasma concentrations of glucagon (hyperglucagonemia). Hyperglucagonemia and alpha-cell hyperplasia may result from elevated levels of plasma amino acids when glucagon's action on hepatic amino acid metabolism is disrupted. We therefore measured plasma levels of glucagon and individual amino acids in patients with and without biopsy-verified NAFLD and with and without type T2D. Fasting levels of amino acids and glucagon in plasma were measured, using validated ELISAs and high-performance liquid chromatography, in obese, middle-aged individuals with I) normal glucose tolerance (NGT) and NAFLD, II) T2D and NAFLD, III) T2D without liver disease, and IV) NGT and no liver disease. Elevated levels of total amino acids were observed in participants with NAFLD and NGT compared to NGT controls (1,310±235 µM vs. 937±281 µM, p=0.03) and in T2D and NAFLD compared to T2D without liver disease (1,354±329 µM vs. 511±235 µM, p<0.0001). Particularly amino acids with known glucagonotropic effects (e.g. glutamine) were increased. Plasma levels of total amino acids correlated to plasma levels of glucagon also when adjusting for body mass index (BMI), glycated haemoglobin (HbA1c), and cholesterol levels (β=0.013±0.007, p=0.024). Elevated plasma levels of total amino acids associate with hyperglucagonemia in NAFLD patients independently of glycemic control, BMI or cholesterol - supporting the potential importance of a 'liver-alpha-cell axis' in which glucagon regulates hepatic amino acid metabolism. Fasting hyperglucagonemia as seen in T2D may therefore represent impaired hepatic glucagon action with increasing amino acids levels.

X Demographics

X Demographics

The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 62 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 14 23%
Student > Bachelor 8 13%
Researcher 6 10%
Student > Ph. D. Student 5 8%
Student > Postgraduate 4 6%
Other 7 11%
Unknown 18 29%
Readers by discipline Count As %
Medicine and Dentistry 21 34%
Biochemistry, Genetics and Molecular Biology 8 13%
Nursing and Health Professions 3 5%
Unspecified 2 3%
Agricultural and Biological Sciences 2 3%
Other 6 10%
Unknown 20 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 September 2021.
All research outputs
#6,931,729
of 25,382,440 outputs
Outputs from American Journal of Physiology: Gastrointestinal & Liver Physiology
#528
of 2,218 outputs
Outputs of similar age
#101,644
of 328,838 outputs
Outputs of similar age from American Journal of Physiology: Gastrointestinal & Liver Physiology
#6
of 35 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 2,218 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 328,838 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.