Title |
Monocyte and macrophage immunometabolism in atherosclerosis
|
---|---|
Published in |
Seminars in Immunopathology, October 2017
|
DOI | 10.1007/s00281-017-0656-7 |
Pubmed ID | |
Authors |
Laszlo Groh, Samuel T. Keating, Leo A. B. Joosten, Mihai G. Netea, Niels P. Riksen |
Abstract |
Atherosclerosis is characterized by chronic low grade inflammation of arteries that results in the development of lipid dense plaques. Chronic inflammation induced by Western-type diet is associated with the risk of developing atherosclerosis, and new insights shed light on the importance of metabolic and functional reprogramming in monocytes and macrophages for progression of atherosclerosis. This review aims to provide an overview of our current understanding into how the metabolic reprogramming of glucose, cholesterol, fatty acid, and amino acid metabolism in macrophages contributes to inflammation during atherosclerosis. Recent insights suggest that transcriptional and epigenetic adaptation within innate immune cells (termed trained immunity) play an important role in the pathogenesis of atherosclerosis. We propose that metabolic changes induced by pro-atherogenic lipoproteins partly mediate these changes in trained macrophages. Finally, we discuss the possibility of manipulating cellular metabolism of immune cells for targeted therapeutic intervention against atherosclerosis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 1 | 20% |
United States | 1 | 20% |
Austria | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 2 | 40% |
Members of the public | 2 | 40% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 252 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 38 | 15% |
Student > Master | 32 | 13% |
Student > Bachelor | 31 | 12% |
Researcher | 27 | 11% |
Student > Doctoral Student | 23 | 9% |
Other | 38 | 15% |
Unknown | 63 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 48 | 19% |
Medicine and Dentistry | 35 | 14% |
Immunology and Microbiology | 32 | 13% |
Agricultural and Biological Sciences | 20 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 14 | 6% |
Other | 30 | 12% |
Unknown | 73 | 29% |