Title |
Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2012 update
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Published in |
Hepatology International, May 2012
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DOI | 10.1007/s12072-012-9365-4 |
Pubmed ID | |
Authors |
Yun-Fan Liaw, Jia-Horng Kao, Teerha Piratvisuth, Henry Lik Yuen Chan, Rong-Nan Chien, Chun-Jen Liu, Ed Gane, Stephen Locarnini, Seng-Gee Lim, Kwang-Hyub Han, Deepak Amarapurkar, Graham Cooksley, Wasim Jafri, Rosmawati Mohamed, Jin-Lin Hou, Wan-Long Chuang, Laurentius A. Lesmana, Jose D. Sollano, Dong-Jin Suh, Masao Omata |
Abstract |
Large volume of new data on the natural history and treatment of chronic hepatitis B virus (HBV) infection have become available since 2008. These include further studies in asymptomatic subjects with chronic HBV infection and community-based cohorts, the role of HBV genotype/naturally occurring HBV mutations, the application of non-invasive assessment of hepatic fibrosis and quantitation of HBV surface antigen and new drug or new strategies towards more effective therapy. To update HBV management guidelines, relevant new data were reviewed and assessed by experts from the region, and the significance of the reported findings was discussed and debated. The earlier "Asian-Pacific consensus statement on the management of chronic hepatitis B" was revised accordingly. The key terms used in the statement were also defined. The new guidelines include general management, indications for fibrosis assessment, time to start or stop drug therapy, choice of drug to initiate therapy, when and how to monitor the patients during and after stopping drug therapy. Recommendations on the therapy of patients in special circumstances, including women in childbearing age, patients with antiviral drug resistance, concurrent viral infection, hepatic decompensation, patients receiving immune suppression or chemotherapy and patients in the setting of liver transplantation and hepatocellular carcinoma, are also included. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | <1% |
Indonesia | 1 | <1% |
United Kingdom | 1 | <1% |
Canada | 1 | <1% |
United States | 1 | <1% |
Unknown | 248 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 38 | 15% |
Other | 27 | 11% |
Student > Bachelor | 23 | 9% |
Student > Ph. D. Student | 22 | 9% |
Student > Postgraduate | 21 | 8% |
Other | 58 | 23% |
Unknown | 64 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 114 | 45% |
Agricultural and Biological Sciences | 17 | 7% |
Biochemistry, Genetics and Molecular Biology | 16 | 6% |
Immunology and Microbiology | 8 | 3% |
Social Sciences | 6 | 2% |
Other | 21 | 8% |
Unknown | 71 | 28% |