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Analysis of sociability and preference for social novelty in the acute and subchronic phencyclidine rat

Overview of attention for article published in Journal of Psychopharmacology, August 2014
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Title
Analysis of sociability and preference for social novelty in the acute and subchronic phencyclidine rat
Published in
Journal of Psychopharmacology, August 2014
DOI 10.1177/0269881114544778
Pubmed ID
Authors

Claire E McKibben, Gavin P Reynolds, Trisha A Jenkins

Abstract

Both acute and sub-chronic phencyclidine administration produce behavioural and pathophysiological changes that resemble some features of schizophrenia. The present study aimed to determine if acute and sub-chronic phencyclidine treatment in male rats produces deficits in sociability and social novelty preference, which may reflect aspects of the negative symptomatology observed in schizophrenia. Rats were treated with phencyclidine acutely (2 or 5 mg/kg) or subchronically (2 or 5 mg/kg bi-daily for one week followed by a one week wash-out period) or vehicle. Social affiliative behaviour was assessed using the sociability and preference for social novelty paradigm where social interaction time was measured in (a) a chamber containing an unfamiliar conspecific vs an empty chamber (sociability), or (b) a chamber containing an unfamiliar conspecific vs a chamber containing a familiar conspecific (preference for social novelty). Results showed that acute administration of phencyclidine produced a reduction in measures of sociability but had no effect on preference for social novelty while sub-chronic administration of phencyclidine had no effect on sociability or social novelty. This study provides further evidence for the usefulness of phencyclidine models in modelling the symptomatology of schizophrenia.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 39 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 23%
Student > Master 7 18%
Student > Bachelor 7 18%
Researcher 5 13%
Other 1 3%
Other 2 5%
Unknown 8 21%
Readers by discipline Count As %
Neuroscience 11 28%
Agricultural and Biological Sciences 6 15%
Pharmacology, Toxicology and Pharmaceutical Science 4 10%
Psychology 4 10%
Medicine and Dentistry 3 8%
Other 3 8%
Unknown 8 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 September 2014.
All research outputs
#20,237,640
of 22,764,165 outputs
Outputs from Journal of Psychopharmacology
#1,724
of 1,930 outputs
Outputs of similar age
#194,308
of 231,146 outputs
Outputs of similar age from Journal of Psychopharmacology
#29
of 34 outputs
Altmetric has tracked 22,764,165 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,930 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.8. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 231,146 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.