| Title |
Advanced Basal Cell Carcinoma: Epidemiology and Therapeutic Innovations
|
|---|---|
| Published in |
Current Dermatology Reports, February 2014
|
| DOI | 10.1007/s13671-014-0069-y |
| Pubmed ID | |
| Authors |
Shalini V. Mohan, Anne Lynn S. Chang |
| Abstract |
Advanced basal cell carcinomas are a subset of basal cell carcinomas that can be difficult to treat either due to their local invasiveness, proximity to vital structures, or metastasis. The incidence of all basal cell carcinoma is increasing in the United States, although it is not known whether advanced basal cell carcinomas (aBCCs) are also increasing. Recently, highly targeted therapy based on knowledge of the basal cell carcinoma pathogenesis has become available either commercially or through human clinical trials. These orally available drugs inhibit the Hedgehog signaling pathway, and lead to advanced basal cell carcinoma shrinkage that can enable preservation of adjacent vital organs. In this review, we outline the role of Hedgehog pathway inhibitors as well as other treatment modalities such as excision, radiotherapy and more traditional chemotherapy in treating advanced basal cell carcinomas. We also highlight current gaps in knowledge regarding the use and side effects of this targeted therapy. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 196 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 1 | <1% |
| Unknown | 195 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 31 | 16% |
| Student > Master | 24 | 12% |
| Researcher | 21 | 11% |
| Student > Ph. D. Student | 19 | 10% |
| Student > Doctoral Student | 18 | 9% |
| Other | 35 | 18% |
| Unknown | 48 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 79 | 40% |
| Biochemistry, Genetics and Molecular Biology | 13 | 7% |
| Agricultural and Biological Sciences | 12 | 6% |
| Engineering | 9 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 4% |
| Other | 25 | 13% |
| Unknown | 50 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 June 2023.
All research outputs
#1,958,994
of 22,931,367 outputs
Outputs from Current Dermatology Reports
#9
of 122 outputs
Outputs of similar age
#24,825
of 311,156 outputs
Outputs of similar age from Current Dermatology Reports
#3
of 6 outputs
Altmetric has tracked 22,931,367 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 122 research outputs from this source. They receive a mean Attention Score of 4.7. This one has done particularly well, scoring higher than 92% of its peers.
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We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.