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Kortikoide im Management des fortgeschrittenen Prostatakarzinoms

Overview of attention for article published in Die Urologie, November 2016
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Title
Kortikoide im Management des fortgeschrittenen Prostatakarzinoms
Published in
Die Urologie, November 2016
DOI 10.1007/s00120-016-0276-1
Pubmed ID
Authors

H. Kübler

Abstract

Corticosteroids have been widely used for decades in cancer therapy, predominantly due to their anti-inflammatory activity. In the treatment of metastatic castration-resistant prostate cancer (mCRPC), corticosteroids play an important role both in the management of tumor-related symptoms, especially bone metastasis-related pain, and as concomitant treatment to counteract side effects associated with approved active prostatic anticancer agents such as docetaxel, cabazitaxel, and abiraterone acetate. In association with abiraterone acetate, low-dose corticosteroids (prednisone or prednisolone) reduce the mineralocorticoid side effects of abiraterone. In addition, corticosteroids may exert direct antitumoral activities, resulting in PSA decline.

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Geographical breakdown

Country Count As %
Unknown 2 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 1 50%
Other 1 50%
Readers by discipline Count As %
Medicine and Dentistry 2 100%