| Title |
Discrepancies between biomarkers of primary breast cancer and subsequent brain metastases: an international multicenter study
|
|---|---|
| Published in |
Breast Cancer Research and Treatment, October 2017
|
| DOI | 10.1007/s10549-017-4526-8 |
| Pubmed ID | |
| Authors |
O. Kaidar-Person, I. Meattini, P. Jain, P. Bult, N. Simone, I. Kindts, R. Steffens, C. Weltens, P. Navarria, Y. Belkacemi, J. Lopez-Guerra, L. Livi, B. G. Baumert, B. Vieites, D. Limon, N. Kurman, K. Ko, J. B. Yu, V. Chiang, P. Poortmans, T. Zagar |
| Abstract |
Discordances between the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), expression between primary breast tumors and their subsequent brain metastases (BM) were investigated in breast cancer patients. We collected retrospective data from 11 institutions in 8 countries in a predefined-standardized format. Receptor status (positive or negative) was determined according to institutional guidelines (immunohistochemically and/or fluorescence in situ hybridization). The study was subject to each institution's ethical research committee. A total of 167 breast cancer patients with BM were included. 25 patients out of 129 with a complete receptor information from both primary tumor and BM (ER, PR, HER2) available, had a change in receptor status: 7 of 26 (27%) ER/PR-positive/HER2-negative primaries (3 gained HER2; 4 lost expression of ER/PR); 10 of 31 (32%) ER/PR-positive/HER2-positive primaries (4 lost ER/PR only; 3 lost HER2 only; 3 lost both ER/PR and HER2); one of 33 (3%) ER/PR-negative receptor/HER2-positive primaries (gained ER); and 7 of 39 (18%) triple-negative primaries (5 gained ER/PR and 2 gained HER2). The majority of breast cancer patients with BM in this series had primary HER2-enriched tumors, followed by those with a triple-negative profile. One out of 5 patients had a receptor discrepancy between the primary tumor and subsequent BM. Therefore, we advise receptor status assessment of BM in all breast cancer patients with available histology as it may have significant implications for therapy. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 49 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 6 | 12% |
| Student > Ph. D. Student | 6 | 12% |
| Researcher | 5 | 10% |
| Professor > Associate Professor | 3 | 6% |
| Professor | 2 | 4% |
| Other | 9 | 18% |
| Unknown | 18 | 37% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 19 | 39% |
| Agricultural and Biological Sciences | 2 | 4% |
| Neuroscience | 2 | 4% |
| Nursing and Health Professions | 1 | 2% |
| Psychology | 1 | 2% |
| Other | 3 | 6% |
| Unknown | 21 | 43% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 October 2018.
All research outputs
#18,573,839
of 23,005,189 outputs
Outputs from Breast Cancer Research and Treatment
#3,739
of 4,681 outputs
Outputs of similar age
#247,363
of 323,064 outputs
Outputs of similar age from Breast Cancer Research and Treatment
#59
of 72 outputs
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