Title |
Schizophrenia and the gut–brain axis
|
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Published in |
Progress in Neuro-Psychopharmacology & Biological Psychiatry, September 2014
|
DOI | 10.1016/j.pnpbp.2014.08.018 |
Pubmed ID | |
Authors |
Katlyn Nemani, Reza Hosseini Ghomi, Beth McCormick, Xiaoduo Fan |
Abstract |
Several risk factors for the development of schizophrenia can be linked through a common pathway in the intestinal tract. It is now increasingly recognized that bidirectional communication exists between the brain and the gut that uses neural, hormonal, and immunological routes. An increased incidence of gastrointestinal (GI) barrier dysfunction, food antigen sensitivity, inflammation, and the metabolic syndrome is seen in schizophrenia. These findings may be influenced by the composition of the gut microbiota. A significant subgroup of patients may benefit from the initiation of a gluten and casein-free diet. Antimicrobials and probiotics have therapeutic potential for reducing the metabolic dysfunction and immune dysregulation seen in patients with schizophrenia. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 29% |
United States | 2 | 29% |
Colombia | 1 | 14% |
Unknown | 2 | 29% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 57% |
Practitioners (doctors, other healthcare professionals) | 2 | 29% |
Scientists | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | <1% |
Australia | 1 | <1% |
Italy | 1 | <1% |
Canada | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 377 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 66 | 17% |
Student > Master | 62 | 16% |
Researcher | 46 | 12% |
Student > Ph. D. Student | 42 | 11% |
Other | 21 | 5% |
Other | 66 | 17% |
Unknown | 80 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 79 | 21% |
Agricultural and Biological Sciences | 52 | 14% |
Biochemistry, Genetics and Molecular Biology | 45 | 12% |
Neuroscience | 36 | 9% |
Psychology | 26 | 7% |
Other | 48 | 13% |
Unknown | 97 | 25% |