| Title |
Anti-dsDNA antibodies in Brazilian patients of mainly African descent with systemic lupus erythematosus: lack of association with lupus nephritis
|
|---|---|
| Published in |
Clinical Rheumatology, March 2009
|
| DOI | 10.1007/s10067-009-1134-y |
| Pubmed ID | |
| Authors |
A. M. Atta, M. M. Pereira, M. Santiago, M. L. B. Sousa-Atta |
| Abstract |
Renal disease is associated with morbidity and mortality in systemic lupus erythematosus (SLE) and anti-dsDNA antibodies with SLE immunopathogenesis. We investigated the dsDNA antibody profile of 84 Brazilian SLE patients, 27 with lupus nephritis. Thirty-six (39.1%) patients had dsDNA IgG antibodies shown in enzyme-linked immunosorbent assay (454.7 +/- 281.1 WHO units/mL), nine presenting renal disease. The following profile of dsDNA antibodies was demonstrated in Crithidia luciliae test: IgA (seven out of 36; 19.4%), IgG (22 out of 36, 66.1%); IgM (nine out of 36, 25.0%), and IgE (four out of 36, 11.1%). Two or three isotypes of dsDNA antibodies were observed in nine (25.0%) patients, while 11 (30.5%) were seronegative in the C. luciliae test. Patients with dsDNA antibodies had lower serum C3 and C4 when compared with SLE individuals without these immunoglobulins (P < 0.01 and P < 0.001, respectively). There was no association between any dsDNA antibody isotype and lupus kidney disease nor was anti-dsDNA IgM antibody associated with absence of nephritis. |
Mendeley readers
The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 27 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Postgraduate | 5 | 19% |
| Lecturer | 5 | 19% |
| Student > Ph. D. Student | 4 | 15% |
| Other | 3 | 11% |
| Student > Master | 2 | 7% |
| Other | 5 | 19% |
| Unknown | 3 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 16 | 59% |
| Immunology and Microbiology | 3 | 11% |
| Agricultural and Biological Sciences | 2 | 7% |
| Psychology | 1 | 4% |
| Unknown | 5 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 September 2014.
All research outputs
#20,237,640
of 22,764,165 outputs
Outputs from Clinical Rheumatology
#2,617
of 2,991 outputs
Outputs of similar age
#91,307
of 94,950 outputs
Outputs of similar age from Clinical Rheumatology
#19
of 19 outputs
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