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Intrauterine devices and endometrial cancer risk: A pooled analysis of the Epidemiology of Endometrial Cancer Consortium

Overview of attention for article published in International Journal of Cancer, September 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Mentioned by

news
3 news outlets
blogs
1 blog
policy
1 policy source
twitter
1 X user
facebook
2 Facebook pages

Citations

dimensions_citation
54 Dimensions

Readers on

mendeley
94 Mendeley
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Title
Intrauterine devices and endometrial cancer risk: A pooled analysis of the Epidemiology of Endometrial Cancer Consortium
Published in
International Journal of Cancer, September 2014
DOI 10.1002/ijc.29229
Pubmed ID
Authors

Ashley S. Felix, Mia M. Gaudet, Carlo La Vecchia, Christina M. Nagle, Xiao Ou Shu, Elisabete Weiderpass, Hans Olov Adami, Shirley Beresford, Leslie Bernstein, Chu Chen, Linda S. Cook, Immaculata De Vivo, Jennifer A. Doherty, Christine M. Friedenreich, Susan M. Gapstur, Dierdre Hill, Pamela L. Horn‐Ross, James V. Lacey, Fabio Levi, Xiaolin Liang, Lingeng Lu, Anthony Magliocco, Susan E. McCann, Eva Negri, Sara H. Olson, Julie R. Palmer, Alpa V. Patel, Stacey Petruzella, Jennifer Prescott, Harvey A. Risch, Lynn Rosenberg, Mark E. Sherman, Amanda B. Spurdle, Penelope M. Webb, Lauren A. Wise, Yong‐Bing Xiang, Wanghong Xu, Hannah P. Yang, Herbert Yu, Anne Zeleniuch‐Jacquotte, Louise A. Brinton

Abstract

Intrauterine devices (IUDs), long-acting and reversible contraceptives, induce a number of immunological and biochemical changes in the uterine environment that could affect endometrial cancer (EC) risk. We addressed this relationship through a pooled analysis of data collected in the Epidemiology of Endometrial Cancer Consortium. We combined individual-level data from 4 cohort and 14 case-control studies, in total 8,801 EC cases and 15,357 controls. Using multivariable logistic regression, we estimated pooled odds ratios (pooled-ORs) and 95% confidence intervals (CIs) for EC risk associated with ever use, type of device, ages at first and last use, duration of use and time since last use, stratified by study and adjusted for confounders. Ever use of IUDs was inversely related to EC risk (pooled-OR = 0.81, 95% CI = 0.74-0.90). Compared with never use, reduced risk of EC was observed for inert IUDs (pooled-OR = 0.69, 95% CI = 0.58-0.82), older age at first use (≥35 years pooled-OR = 0.53, 95% CI = 0.43-0.67), older age at last use (≥45 years pooled-OR = 0.60, 95% CI = 0.50-0.72), longer duration of use (≥10 years pooled-OR = 0.61, 95% CI = 0.52-0.71) and recent use (within 1 year of study entry pooled-OR = 0.39, 95% CI = 0.30-0.49). Future studies are needed to assess the respective roles of detection biases and biologic effects related to foreign body responses in the endometrium, heavier bleeding (and increased clearance of carcinogenic cells) and localized hormonal changes.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 94 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Mexico 1 1%
United States 1 1%
Unknown 91 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 13 14%
Researcher 11 12%
Student > Ph. D. Student 10 11%
Student > Bachelor 10 11%
Student > Postgraduate 8 9%
Other 16 17%
Unknown 26 28%
Readers by discipline Count As %
Medicine and Dentistry 34 36%
Nursing and Health Professions 6 6%
Biochemistry, Genetics and Molecular Biology 5 5%
Social Sciences 4 4%
Pharmacology, Toxicology and Pharmaceutical Science 3 3%
Other 12 13%
Unknown 30 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 39. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 April 2024.
All research outputs
#1,075,963
of 25,718,113 outputs
Outputs from International Journal of Cancer
#333
of 12,271 outputs
Outputs of similar age
#11,343
of 265,427 outputs
Outputs of similar age from International Journal of Cancer
#8
of 124 outputs
Altmetric has tracked 25,718,113 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,271 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,427 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 124 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.