| Title |
Prognostic value of coronary atherosclerosis progression evaluated by coronary CT angiography in patients with stable angina
|
|---|---|
| Published in |
European Radiology, September 2017
|
| DOI | 10.1007/s00330-017-5073-8 |
| Pubmed ID | |
| Authors |
Hui Gu, Yang Gao, Zhihui Hou, U. Joseph Schoepf, Alan N. Snyder, Taylor M. Duguay, Ximing Wang, Bin Lu |
| Abstract |
To investigate the progression of coronary atherosclerosis burden by coronary CT angiography (CCTA) and to demonstrate its association with the incidence of major adverse cardiac events (MACE). We retrospectively studied patients with stable angina who had undergone repeat CCTA due to recurrent or worsening symptoms. Lipid-rich, fibrous, calcified and total plaque burden as well as coronary diameter stenosis were quantitatively analysed. The incidence of MACE during follow-up was determined. The final cohort consisted of 268 patients (mean age 52.9 ± 9.8 years, 71 % male) with a mean follow-up period of 4.6 ± 0.9 years. Patients with lipid-rich, fibrous, calcified and total plaque burden (%) progression, as well as coronary diameter stenosis (%) progression had a significantly higher incidence of MACE than those without (all p < 0.05). The progression of lipid-rich plaque (HR = 1.601, p = 0.021), total plaque burden (HR = 2.979, p = 0.043) and coronary diameter stenosis (HR = 4.327, p <0.001) were independent predictors of MACE (all p < 0.05). Patients presenting with recurrent or worsening symptoms associated with coronary artery disease who have coronary atherosclerosis progression on CCTA are at an increased risk of future MACE. • Repeat CCTA can provide information regarding the progression of coronary atherosclerosis. • Coronary atherosclerosis progression at CCTA is independently associated with MACE. • CCTA findings could serve as incremental predictors of MACE. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 22 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 3 | 14% |
| Other | 2 | 9% |
| Student > Doctoral Student | 2 | 9% |
| Student > Master | 2 | 9% |
| Student > Postgraduate | 2 | 9% |
| Other | 3 | 14% |
| Unknown | 8 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 7 | 32% |
| Neuroscience | 2 | 9% |
| Social Sciences | 1 | 5% |
| Computer Science | 1 | 5% |
| Materials Science | 1 | 5% |
| Other | 1 | 5% |
| Unknown | 9 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 July 2018.
All research outputs
#16,242,268
of 23,934,504 outputs
Outputs from European Radiology
#2,599
of 4,428 outputs
Outputs of similar age
#205,599
of 323,991 outputs
Outputs of similar age from European Radiology
#38
of 59 outputs
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