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Mendeley readers
Attention Score in Context
| Title |
Delayed animal aging through the recovery of stem cell senescence by platelet rich plasma
|
|---|---|
| Published in |
Clinical Materials, September 2014
|
| DOI | 10.1016/j.biomaterials.2014.08.034 |
| Pubmed ID | |
| Authors |
Hen-Yu Liu, Chiung-Fang Huang, Tzu-Chieh Lin, Ching-Yu Tsai, Szu-Yu Tina Chen, Alice Liu, Wei-Hong Chen, Hong-Jian Wei, Ming-Fu Wang, David F. Williams, Win-Ping Deng |
| Abstract |
Aging is related to loss of functional stem cell accompanying loss of tissue and organ regeneration potentials. Previously, we demonstrated that the life span of ovariectomy-senescence accelerated mice (OVX-SAMP8) was significantly prolonged and similar to that of the congenic senescence-resistant strain of mice after platelet rich plasma (PRP)/embryonic fibroblast transplantation. The aim of this study is to investigate the potential of PRP for recovering cellular potential from senescence and then delaying animal aging. We first examined whether stem cells would be senescent in aged mice compared to young mice. Primary adipose derived stem cells (ADSCs) and bone marrow derived stem cells (BMSCs) were harvested from young and aged mice, and found that cell senescence was strongly correlated to animal aging. Subsequently, we demonstrated that PRP could recover cell potential from senescence, such as promote cell growth (cell proliferation and colony formation), increase osteogenesis, decrease adipogenesis, restore cell senescence related markers and resist the oxidative stress in stem cells from aged mice. The results also showed that PRP treatment in aged mice could delay mice aging as indicated by survival, body weight and aging phenotypes (behavior and gross morphology) in term of recovering the cellular potential of their stem cells compared to the results on aged control mice. In conclusion these findings showed that PRP has potential to delay aging through the recovery of stem cell senescence and could be used as an alternative medicine for tissue regeneration and future rejuvenation. |
Mendeley readers
The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Unknown | 72 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 12 | 16% |
| Student > Ph. D. Student | 12 | 16% |
| Researcher | 11 | 15% |
| Student > Doctoral Student | 6 | 8% |
| Student > Bachelor | 4 | 5% |
| Other | 12 | 16% |
| Unknown | 16 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 19 | 26% |
| Biochemistry, Genetics and Molecular Biology | 11 | 15% |
| Agricultural and Biological Sciences | 8 | 11% |
| Unspecified | 4 | 5% |
| Materials Science | 3 | 4% |
| Other | 11 | 15% |
| Unknown | 17 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 February 2015.
All research outputs
#4,162,221
of 25,394,764 outputs
Outputs from Clinical Materials
#1,855
of 10,758 outputs
Outputs of similar age
#40,594
of 246,452 outputs
Outputs of similar age from Clinical Materials
#15
of 82 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 10,758 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 246,452 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 82 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.